Epidemiol Health.
2023;45(1):e2023091. 10.4178/epih.e2023091.
Cohort profile: investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort
- Azeez R
1,2 - Lotoski L2,3
- Dubeau A4,5
- Rodriguez N2,3
- Reyna ME4
- Freitas T5
- Goguen S2,3
- Medeleanu M4
- Winsor GL6
- Brinkman FSL6
- Cameron EE7
- Roos L2,7
- Simons E2,3
- Moraes TJ4
- Mandhane PJ8
- Turvey SE9
- Bolotin S10
- Wright K5
- McNeil D11,12
- Patrick DM13,14
- Bullard J2,15
- Langlois MA16
- Arnold CR16
- Galipeau Y16
- Pelchat M16
- Doucas N17
- Subbarao P4,5
- Azad MB1,2,3
- Affiliations
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- 1Department of Immunology, University of Manitoba, Winnipeg, MB, Canada
- 2Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
- 3Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
- 4Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
- 5Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
- 6Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
- 7Department of Psychology, University of Manitoba, Winnipeg, MB, Canada
- 8Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
- 9Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
- 10Centre for Vaccine Preventable Diseases, University of Toronto; Dalla Lana School of Public Health, University of Toronto; Department of Laboratory Medicine and Pathobiology, University of Toronto; Public Health Ontario, ON, Canada
- 11Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
- 12Strategic Clinical Networks, Alberta Health Services, Calgary, AB, Canada
- 13School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
- 14British Columbia Centre for Disease Control, Vancouver, BC, Canada
- 15Cadham Provincial Laboratory, Manitoba Health, Winnipeg, MB, Canada
- 16Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
- 17CHILD Cohort Study National Parent Engagement Committee
- KMID: 2552294
- DOI: http://doi.org/10.4178/epih.e2023091
Abstract
- The coronavirus disease 2019 (COVID-19) pandemic has affected all Canadian families, with some impacted differently than others. Our study aims to: (1) determine the prevalence and transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among Canadian families, (2) identify predictors of infection susceptibility and severity of SARS-CoV-2, and (3) identify health and psychosocial impacts of the COVID-19 pandemic. This study builds upon the CHILD Cohort Study, an ongoing multi-ethnic general population prospective cohort consisting of 3,454 Canadian families with children born in Vancouver, Edmonton, Manitoba, and Toronto between 2009 and 2012. During the pandemic, CHILD households were invited to participate in the CHILD COVID-19 Add-On Study involving: (1) brief biweekly surveys about COVID-19 symptoms and testing; (2) quarterly questionnaires assessing COVID-19 exposure and testing, vaccination status, physical and mental health, and pandemic-driven life changes; and (3) in-home biological sampling kits to collect blood and stool. In total, 1,462 households (5,378 participants) consented to the CHILD COVID-19 Add-On Study: 2,803 children (mean±standard deviation [SD], 9.0±2.7 years; range, 0-17 years) and 2,576 adults (mean±SD, 43.0±6.5 years; range, 18-85 years). We will leverage the wealth of pre-pandemic CHILD data to identify risk and resilience factors for susceptibility and severity to the direct and indirect pandemic effects. Our short-term findings will inform key stakeholders and knowledge users to shape current and future pandemic responses. Additionally, this study provides a unique resource to study the long-term impacts of the pandemic as the CHILD Cohort Study continues.
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