Infect Chemother.  2020 Jun;52(2):154-164. 10.3947/ic.2020.52.2.154.

Age-Related Morbidity and Mortality among Patients with COVID-19

  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea


On March 11, 2020, the World Health Organization declared coronavirus disease (COVID-19), caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a pandemic. During the COVID-19 pandemic, an age-associated vulnerability in the burden of disease has been uncovered. Understanding the spectrum of illness and the pathogenic mechanism of the disease in a vulnerable population is critical, especially during the pandemic. Herein, we reviewed published COVID-19 epidemiology data from several countries to identify any consistent trends in the relationship between age and COVID-19-associated morbidity or mortality. We also reviewed the literature for studies explaining the difference in the host response to SARS-CoV-2 infection according to age. The insights from these data will be useful in determining the treatment policies and preventive measures of COVID-19.


COVID-19; Pandemic; Age; Morbidity; Mortality
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