Ann Lab Med.  2023 Nov;43(6):628-631. 10.3343/alm.2023.43.6.628.

Improving the Work Efficiency of Therapeutic Drug Monitoring Reports Through the Establishment of an Automated Data Transfer System

• Lee S
• Yoon S
• Kim HK
• Kim S
• Lee W
• Chun S
• Min WK

• KMID: 2552042
• DOI: http://doi.org/10.3343/alm.2023.43.6.628

Figure

• 

  Fig. 1 Automated data transference system at Asan Medical Center. (A) The interface software. This software loads patient information, laboratory information, and drug dosing history from electronic health records, which are essential to calculate the area under curve in MwPharm++. (B) The data are exported to two text files by clicking the “Generate .txt” button. (C) In-house keyboard-mouse macro software. By clicking the “Start” button, this software automatically inputs the data in .txt files into MwPharm++. (D) A screenshot of MwPharm++. The data described in Figure 1B were automatically entered into MwPharm++ through the macro software.

Reference

1. Koh YR, Kim KH, Chang CL, Yi J. 2016; Prevalence and clinical impact of heterogeneous vancomycin-intermediate Staphylococcus aureus isolated from hospitalized patients. Ann Lab Med. 36:235–43. DOI: 10.3343/alm.2016.36.3.235. PMID: 26915612. PMCID: PMC4773264.

2. Monteiro JF, Hahn SR, Gonçalves J, Fresco P. 2018; Vancomycin therapeutic drug monitoring and population pharmacokinetic models in special patient subpopulations. Pharmacol Res Perspect. 6:e00420. DOI: 10.1002/prp2.420. PMID: 30156005. PMCID: PMC6113434.

3. Álvarez R, López Cortés LE, Molina J, Cisneros JM, Pachón J. 2016; Optimizing the clinical use of vancomycin. Antimicrob Agents Chemother. 60:2601–9. DOI: 10.1128/AAC.03147-14. PMID: 26856841. PMCID: PMC4862470.

4. Rybak M, Lomaestro B, Rotschafer JC, Moellering R Jr, Craig W, Billeter M, et al. 2009; Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 66:82–98. DOI: 10.2146/ajhp080434. PMID: 19106348.

5. Rybak MJ, Le J, Lodise TP, Levine DP, Bradley JS, Liu C, et al. 2020; Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: a revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 77:835–64. DOI: 10.1093/ajhp/zxaa036. PMID: 32191793.

6. Van Der Heggen T, Buyle FM, Claus B, Somers A, Schelstraete P, De Paepe P, et al. 2021; Vancomycin dosing and therapeutic drug monitoring practices: guidelines versus real-life. Int J Clin Pharm. 43:1394–403. DOI: 10.1007/s11096-021-01266-7. PMID: 33913087.

7. Fuchs A, Csajka C, Thoma Y, Buclin T, Widmer N. 2013; Benchmarking therapeutic drug monitoring software: a review of available computer tools. Clin Pharmacokinet. 52:9–22. DOI: 10.1007/s40262-012-0020-y. PMID: 23196713.

8. Kantasiripitak W, Van Daele R, Gijsen M, Ferrante M, Spriet I, Dreesen E. 2020; Software tools for model-informed precision dosing: how well do they satisfy the needs? Front Pharmacol. 11:620. DOI: 10.3389/fphar.2020.00620. PMID: 32457619. PMCID: PMC7224248.

9. Dubovitskaya A, Buclin T, Schumacher M, Aberer K, Thoma Y. 2017. TUCUXI: an intelligent system for personalized medicine from individualization of treatments to research databases and back. Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics. p. 223–32.

10. Roggeveen LF, Guo T, Driessen RH, Fleuren LM, Thoral P, van der Voort PHJ, et al. 2020; Right dose, right now: development of autokinetics for real time model informed precision antibiotic dosing decision support at the bedside of critically ill patients. Front Pharmacol. 11:646. DOI: 10.3389/fphar.2020.00646. PMID: 32499697. PMCID: PMC7243359.