J Menopausal Med.
2023 Dec;29(3):92-96. 10.6118/jmm.23032.
Tibolone and Breast Cancer
- Affiliations
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- 1Departments of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea
- 2Institute of Women’s Life Medical Science, Yonsei University College of Medicine, Seoul, Korea
- KMID: 2550639
- DOI: http://doi.org/10.6118/jmm.23032
Abstract
- Tibolone, a selective tissue estrogenic activity regulator, is a synthetic steroid with distinct pharmacological and clinical characteristics in contrast to conventional menopausal hormone therapy. Tibolone induces estrogenic activity in the brain, vagina, and bone but remains inactive in the endometrium and breast. In particular, several studies have investigated whether tibolone usage increases the risk of breast cancer. This study aims to determine the effects of tibolone on the breast by focusing on the relation between tibolone use and breast cancer. Our investigation emphasizes recent studies, particularly those based on Asian populations.
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