Ann Dermatol.
2023 Nov;35(Suppl2):S201-S204. 10.5021/ad.21.215.
Acral Pigmentation in Peutz-Jeghers Syndrome: Dermoscopic Findings and Treatment with the Q-Switched Nd:YAG Laser
- Affiliations
-
- 1Department of Premedicine, Seoul National University College of Medicine, Seoul, Korea
- 2Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea
- 3Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2548842
- DOI: http://doi.org/10.5021/ad.21.215
Abstract
- Peutz-Jeghers syndrome (PJS; MIM 175200) is an autosomal dominant multiple-organ cancer syndrome. It is characterized by brown macules distributed in the perioral skin, oral mucosa, hands and feet, and hamartomatous gastrointestinal polyps that can eventually lead to intestinal obstruction, abdominal pain, bleeding, and anemia. Patients with PJS are at a higher risk of ovarian, testicular, breast, lung, and pancreatic cancers. This predisposition is due to the pathogenic variant in serine/threonine kinase 11 (STK11) gene located on chromosome 19p13.3. Here, we present the dermoscopic findings, histopathologic features of acral pigmentation, and DNA sequencing results of the patient with PJS. We also report a successful removal of acral pigmentation using the Q-switched Nd:YAG laser (QSNYL) treatment. Our results suggest that QSNYL therapy could be a treatment option for acral pigmentation in patients with PJS.
