J Bone Metab.
2023 Nov;30(4):311-317. 10.11005/jbm.2023.30.4.311.
Effectiveness and Usefulness of Bone Turnover Marker in Osteoporosis Patients: A Multicenter Study in Korea
- Yoo JI
1 - Park SY2
- Kim DY3
- Ha J4
- Rhee Y5
- Hong N5
- Kim JT6
- Yi HS7,8,9
- Kim BK10
- Lee YK11
- Ha YC12
- Jeon YK13
- Kim HY14
- Ahn SH15
- Hong S15
- Lee SY16
- Affiliations
-
- 1Department of Orthopaedic Surgery, Inha University Hospital, Inha University School of Medicine, Incheon, Korea
- 2Division of Endocrinology and Metabolism, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea
- 3Department of Nuclear Medicine, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea
- 4Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 5Department of Internal Medicine, Endocrine Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 6Department of Orthopedic Surgery, Ajou Medical Center, Ajou University School of Medicine, Suwon, Korea
- 7Laboratory of Endocrinology and Immune System, Chungnam National University School of Medicine, Daejeon, Korea
- 8Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Korea
- 9Division of Endocrinology and Metabolism, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
- 10Division of Endocrinology and Metabolism, Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea
- 11Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
- 12Department of Orthopaedic Surgery, Seoul Bumin Hospital, Seoul, Korea
- 13Division of Endocrinology and Metabolism, Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea
- 14Division of Endocrinology and Metabolism, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea
- 15Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea
- 16Department of Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, Korea
- KMID: 2548586
- DOI: http://doi.org/10.11005/jbm.2023.30.4.311
Abstract
- Background
This study aimed to investigate real-world data of C-terminal telopeptide (CTX), propeptide of type I collagen (P1NP), and osteocalcin through present multicenter clinical study, and retrospectively analyze the usefulness of bone turnover markers (BTMs) in Koreans.
Methods
The study focused on pre- and post-menopausal patients diagnosed with osteoporosis and excluded patients without certain test results or with test intervals of over 1 year. The demographic data and 3 BTMs (CTX, P1NP, and osteocalcin) were collected. The patients were classified by demographic characteristics and the BTM concentrations were analyzed by the group.
Results
Among women with no history of fractures, the levels of P1NP (N=2,100) were 43.544±36.902, CTX (N=1,855) were 0.373 ±0.927, and osteocalcin (N=219) were 10.81 ±20.631. Among men with no history of fractures, the levels of P1NP (N=221) were 48.498±52.892, CTX (N=201) were 0.370±0.351, and osteocalcin (N=15) were 7.868 ±10.674. Treatment with teriparatide increased the P1NP levels after 3 months in both men and women, with a 50% increase observed in women. Similarly, treatment with denosumab decreased the CTX levels after 3 months in both men and women, with a reduction of 50% observed in women.
Conclusions
The results of this study can contribute to the accurate assessment of bone replacement status in Koreans. We also provide the P1NP level in the Korean population for future comparative studies with other populations.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Changes of Biochemical Markers of Bone turnover in Pre-, Peri-and Postmenopausal Women
- Biochemical Markers of Bone Turnover
- The Usefulness of Bone Turnover Marker as a Predictive Factor In Osteopenic Postmenopausal Women
- Study for Usefulness of Total Alkaline Phosphatase as a Biochemical Markers of Bone Turnover in Healthy Menopausal Women
- Serum Osteocalcin Measurement by RIA in Bone Diseases Associated with Osteoporosis and Metastatic Cancer
