Int J Heart Fail.  2023 Apr;5(2):82-90. 10.36628/ijhf.2022.0030.

SGLT-2 Inhibitors in Heart Failure: A Review of Current Evidence

• Talha KM
• Anker SD
• Butler J

• KMID: 2547679
• DOI: http://doi.org/10.36628/ijhf.2022.0030

Abstract

Sodium-glucose co-transporter 2 (SGLT-2) inhibitors are the latest addition to guideline-directed medical therapy in heart failure (HF) with reduced ejection fraction with recent trials suggesting a significant reduction in adverse cardiovascular outcomes in patients with HF with mildly reduced and preserved ejection fraction. SGLT-2 inhibitors have evolved as metabolic drugs due to their multi-system effects and are indicated for the management of HF across the ejection fraction spectrum, type 2 diabetes, and chronic kidney disease. There is ongoing research to explore the mechanistic effects of SGLT-2 inhibitors in HF and to evaluate their use in worsening HF and after myocardial infarction. This review focuses on the evidence for SGLT-2 inhibitors from type 2 diabetes cardiovascular outcome and primary HF trials and discusses ongoing research related to their use in cardiovascular disease.

Keyword

Sodium-glucose transporter 2 inhibitors; Heart failure; Systolic; Diastolic