J Korean Neurol Assoc.
2023 Nov;41(4):328-332. 10.17340/jkna.2023.0094.
Intraparenchymal Neurocysticercosis Unmasked by Cessation of Oral Corticosteroids: Immune Evasion and Therapeutic Approaches
- Affiliations
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- 1Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea
- 2Department of Neurology, Seoul National University Hospital, Seoul, Korea
- 3Departments of Neurology, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2547625
- DOI: http://doi.org/10.17340/jkna.2023.0094
Abstract
- In a unique case of neurocysticercosis in Korea, a 73-year-old woman previously treated with steroids for rheumatoid arthritis exhibited neurological symptoms following steroid cessation. Magnetic resonance imaging findings confirmed vesicular stage neurocysticercosis, and subsequent antiparasitic treatment led to symptom resolution. The immunopathology of neurocysticercosis involves intricate interactions between the cyst’s immune evasion mechanisms and host inflammatory responses. The parasites’ strategy of inducing Th2- mediated anti-inflammatory responses for survival suggests potential therapeutic options for autoimmune disorders.
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