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Ocular Flutter in Parainfectious Meningoencephalitis: A Case Report

Yoon IH, Yun SH, Kang BH

Ocular flutter is a rare, horizontal eye movement disorder characterized by intermittent bursts of conjugate horizontal saccades without intersaccadic intervals. It can occur in various clinical conditions such as metabolic...
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Cost-Effectiveness Analysis of Immunotherapy in Patient with Allergic Rhinitis

Park JY, Kim YS, Kim JK, Cho JH

Background and Objectives All treatments must be effective and affordable. Although it is clear that immunotherapy is effective in patients with allergic rhinitis, no cost-effectiveness analysis has been conducted in...
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Amyloid-Targeting Drugs for the Treatment of Alzheimer Disease

Lee AY

Alzheimer’s disease (AD) is the most common cause of dementia, characterized by cognitive impairment, neurobehavioral changes, and loss of functional ability. Current therapeutic options for AD are limited to medications...
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The Application of Machine Learning in Predicting Outcome of Cryotherapy and Immunotherapy for Wart Removal

Singh Y

Background: Warts can be extremely painful conditions that may be associated with localised bleeding and discharge. They are commonly treated by cryotherapy or immunotherapy. However, each of these therapies have discomforting...
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Intralesional Purified Protein Derivative Immunotherapy for Warts: A Clinical Study

Choi H, Kim YI, Na CH, Kim MS, Shin BS

  • KMID: 2518985
  • Korean J Dermatol.
  • 2021 Jul;59(6):434-439.
Background: Warts are epidermal growths caused by the human papillomavirus and are commonly observed in dermatology practice. Intralesional immunotherapy is shown to be effective for treatment of warts. However, to...
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Colonic Perforation After Treatment With Nivolumab in Esophageal Cancer: A Case Report

Cho HJ, Kim WR, Kim JH, Kim DH, Kim DJ, Kang H

With the advent of checkpoint inhibitors, it has opened up opportunities for numerous cancer patients. However, as is the case with every treatment, complications need to be weighed. Gastrointestinal adverse...
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Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer

Nam CH, Koh J, Ock CY, Kim M, Keam B, Kim TM, Jeon YK, Kim DW, Chung DH, Heo DS

Background/Aims: Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer. Methods:...
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Enriching CCL3 in the Tumor Microenvironment Facilitates T cell Responses and Improves the Efficacy of Anti-PD-1 Therapy

Kang TG, Park HJ, Moon J, Lee JH, Ha SJ

Chemokines are key factors that influence the migration and maintenance of relevant immune cells into an infected tissue or a tumor microenvironment. Therefore, it is believed that the controlled administration...
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Refractory brainstem encephalitis mimicking progressive cerebral infarction: infliximab and methotrexate as a salvage immunotherapy

Ahn SH, Roh J, Woo KN, Kim HS, Park MG, Park KP, Baik SK, Shin JH

Background: Brainstem encephalitis is a rare, severe, and potentially life-threatening inflammation of the central nervous system, exhibiting various treatment responses and outcomes owing to multiple etiologies. Case Report: We describe...
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Adjuvant therapy using ex vivo-expanded allogenic natural killer cells in hepatectomy patients with hepatitis B virus related solitary hepatocellular carcinoma: MG4101 study

Kim JM, Cho SY, Rhu J, Jung M, Her JH, Lim O, Choi GS, Shin EC, Hwang YK, Joh JW

Backgrounds/Aims: Fewer reports have been published regarding hepatectomy patients with solitary hepatocellular carcinoma (HCC) who received immunotherapeutic agents as adjuvant therapy. We evaluated the safety and efficacy of ex vivo-expanded...
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Analysis of the Dermatologic Side Effects and the Factors Affecting the Efficacy of Immune Checkpoint Inhibitor in Melanoma: A Single-Center, Retrospective Study

Yoon D, Oh SJ, Kim HJ, Park JH, Lee JH, Lee DY, Lee JH

  • KMID: 2516137
  • Korean J Dermatol.
  • 2021 May;59(4):251-258.
Background: Programmed death 1 inhibitors enhance pre-existing immune responses by directly blocking anti-programmed cell death receptor-1. They have been widely used these days, but little is known about the dermatologic...
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Treatment of advanced urogenital cancers with immune checkpoint inhibitors

Jung EH, Kim SH

The development of immune checkpoint inhibitors has improved the long-term survival of patients with several types of cancers, including bladder and renal cell carcinomas. Atezolizumab, an anti-programmed death-ligand 1 monoclonal...
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Programmed cell death-ligand 1 assessment in urothelial carcinoma: prospect and limitation

Lee KS, Choe G

Programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) inhibition has revolutionized the treatment paradigm of urothelial carcinoma (UC). Several PD-L1 assays are conducted to formulate appropriate treatment decisions for PD-1/PD-L1...
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Primary malignant mucosal melanoma of the maxillofacial area

Kim H, Lee S, Cha IH, Kim HJ, Nam W

Objectives: We aimed to collect and report data from all patients who have been diagnosed with mucosal malignant melanoma to obtain the epidemiology and principles of current treatments. Materials and Methods:...
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Immuno-oncology for B-cell lymphomas

Choi YS

The goal of cancer immunotherapy is to restore and optimize the immune response against malignant clones through several stages, from recognition of tumor antigens to establishment of long-lived memory cell...
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Immune Checkpoint Inhibitor with or without Radiotherapy in Melanoma Patients with Brain Metastases: A Systematic Review and Meta-Analysis

Kim, PH, Suh CH, Kim HS, Kim KW, Kim DY, Lee EQ, Aizer AA, Guenette JP, Huang RY

Objective: Immune checkpoint inhibitor (ICI) therapy has shown activity against melanoma brain metastases. Recently, promising results have also been reported for ICI combination therapy and ICI combined with radiotherapy. We...
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The Development of Antibody-Drug Conjugates for Urothelial Carcinoma Treatment

Choi DS, Kang SJ, Chang IH, Choi YW

Urothelial cancer is the seventh most common cancer among men worldwide. Bacille de Calmette-Guérin is a type of anticancer immunotherapy that has been used to treat targeted bladder cancer, but...
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COVID-19 Antiviral and Treatment Candidates: Current Status

Españo E, Kim D, Kim J, Park SK, Kim JK

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 has severely impacted global health and economy. There is currently no effective approved treatment for...
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Safety and Utility of Rush Immunotherapy with Aqueous Allergen Extracts for Treatment of Respiratory Allergies

Lee JH, Choi JH, Jeong KB, Lee SJ, Lee MK, Lee WY, Yong SJ, Kim SH

Background: Generally, allergen immunotherapy must be administered for three to five years. Meanwhile, rush immunotherapy (RIT) shortens the required duration for the build-up phase, thereby improving the therapy's convenience compared...
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Radiation-induced abscopal effect and its enhancement by programmed cell death 1 blockade in the hepatocellular carcinoma: A murine model study

Yoo GS, Ahn WG, Kim SY, Kang W, Choi C, Park HC

Background/Aims: The abscopal effect, a rare phenomenon induced by radiation, can be reinforced by immunotherapy. Although radiation therapy and immunotherapy are increasingly being utilized for the treatment of hepatocellular carcinoma...
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