Korean J Gastroenterol.  2023 Sep;82(3):127-136. 10.4166/kjg.2023.060.

Risk of Hepatitis C Virus Transmission through Acupuncture: A Systematic Review and Meta-Analysis

• Hyun MH
• Kim JH
• Jang JW
• Song JE
• Song DS
• Lee HW
• Cho YY
• Kim GA
• Yoon EL
• Sinn DH
• Kim SS
• Yim SY
• Yang H
• An J

• KMID: 2546514
• DOI: http://doi.org/10.4166/kjg.2023.060

Abstract

Background/Aims
Chronic hepatitis C is a major risk factor for liver cirrhosis, hepatocellular carcinoma, and hepatic failure. Although traditional practices, including acupuncture, tend to increase the risk of HCV infection, the association remains controversial. Therefore, the current meta-analytical study was undertaken to evaluate the risks of acupuncture and hepatitis C transmission.
Methods
Two researchers independently screened studies from the databases encompassing the period from inception to May 12, 2022. Baseline demographics, HCV transmission OR, and 95% CIs were extracted, pooled, and analyzed using random-effect models. Subgroup analyses utilizing study design and ethnicity were performed. Heterogeneity and publication bias were analyzed using the Higgins I² test and funnel plots, respectively.
Results
In all, 28 studies with 194,826 participants (178,583 controls [91.7%] vs. 16,243 acupuncture users [8.3%]) were included in the final analysis. The pooled analysis showed that acupuncture users had a significantly higher HCV transmission rate than controls with heterogeneity (OR, 1.84 [1.46–2.32]; p<0.001; I² =80%). In the subgroup analysis, both cross-sectional case-control (n=14; OR, 1.96 [1.47–2.61]; p<0.001; I² =88%) and cross-sectional studies (n=12; OR, 1.85 [1.32–2.61]; p<0.001; I² =0%) showed significantly higher HCV infection rates in the acupuncture group than in the control group. Both Asian and non-Asian acupuncture users showed a higher HCV transmission risk than the controls (all P_s <0.001). No significant publication bias was observed.
Conclusions
Our findings indicate that acupuncture increases the risk of HCV transmission. Due to HCV's contagiousness, unsafe medical and social practices (including acupuncture) should be performed with caution.

Keyword

Acupuncture; Hepatitis C virus; Transmission; Meta-analysis

Figure

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  Fig. 1 Study flow chart.

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  Fig. 2 Pooled analysis of odds ratio for the association between acupuncture and HCV infection. Each dot represents the OR with a 95% CI. The box size represents the weight of the study in the meta-analysis. Weights were obtained using the random-forest model. M-H, Mantel-Haenszel.

• 

  Fig. 3 Pooled analysis of odds ratio for the association between acupuncture and HCV infection according to study design. Each dot represents the OR with a 95% CI. The box size represents the weight of the study in the meta-analysis. Weights were obtained using the random-forest model. M-H, Mantel-Haenszel.

• 

  Fig. 4 Pooled analysis of odds ratio for the association between acupuncture and HCV infection according to ethnicity. Each dot represents the OR with a 95% CI. The box size represents the weight of the study in the meta-analysis. Weights were obtained using the random-forest model. M-H, Mantel-Haenszel.

• 

  Fig. 5 Funnel plot for the association between acupuncture and HCV infection. SE, standard error.

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