Pediatr Emerg Med J.  2023 Oct;10(4):155-159. 10.22470/pemj.2023.00766.

A case of multisystem inflammatory syndrome in children associated with coronavirus disease 2019, presenting as unremitting fever, vomiting, and rash

Affiliations
  • 1Department of Emergency Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea

Abstract

Multisystem inflammatory syndrome in children, a hyper inflammation syndrome induced by severe acute respiratory syndrome coronavirus 2, may show a fatal progression. Thus, it is important to recognize its symptoms, and provide appropriate treatment at an early stage. We report a 7-year-old boy who presented with unremitted fever, vomiting, and whole-body polymorphic rash. Laboratory findings showed lymphopenia, and elevated erythrocyte sedimentation rate, C-reactive protein, fibrinogen, d-dimer, ferritin, and triglyceride. The boy had negative findings of viruses-related to respiratory disease and meningitis, and positivity for immunoglobulin G against severe acute respiratory syndrome coronavirus 2. He was diagnosed as multisystem inflammatory syndrome in children, and received supportive care, intravenous immunoglobulin, and steroid. He was discharged without complication on day 12.

Keyword

Exanthema; Fever; Mucocutaneous Lymph Node Syndrome; SARS-CoV-2; Vomiting

Figure

  • Fig. 1. Initial plain radiographs. No abnormality was shown on posteroanterior (A) and left lateral (B) views.

  • Fig. 2. Initial electrocardiogram without a ST segment change.


Reference

References

1. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020; 395:1607–8.
2. Belay ED, Abrams J, Oster ME, Giovanni J, Pierce T, Meng L, et al. Trends in geographic and temporal distribution of US children with multisystem inflammatory syndrome during the COVID-19 pandemic. JAMA Pediatr. 2021; 175:837–45.
3. Simon Junior H, Sakano TMS, Rodrigues RM, Eisencraft AP, Carvalho VEL, Schvartsman C, et al. Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician’s point of view. J Pediatr (Rio J). 2021; 97:140–59.
4. Toubiana J, Poirault C, Corsia A, Bajolle F, Fourgeaud J, Angoulvant F, et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020; 369:m2094.
5. Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N Engl J Med. 2020; 383:334–46.
6. Kim L, Whitaker M, O'Halloran A, Kambhampati A, Chai SJ, Reingold A, et al. Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19 - COVID-NET, 14 States, March 1-July 25, 2020. MMWR Morb Mortal Wkly Rep. 2020; 69:1081–8.
7. Rowley AH, Shulman ST, Arditi M. Immune pathogenesis of COVID-19-related multisystem inflammatory syndrome in children. J Clin Invest. 2020; 130:5619–21.
8. Lee JK, Cho EY, Lee H. Multisystem inflammatory syndrome in children (MIS-C). Pediatr Infect Vaccine. 2021; 28:66–81. Korean.
9. Carter MJ, Fish M, Jennings A, Doores KJ, Wellman P, Seow J, et al. Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection. Nat Med. 2020; 26:1701–7.
10. Consiglio CR, Cotugno N, Sardh F, Pou C, Amodio D, Rodriguez L, et al. The immunology of multisystem inflammatory syndrome in children with COVID-19. Cell. 2020; 183:968–81.
11. U.S. Centers for Disease Control and Prevention (CDC). Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) [Internet]. CDC; c2023 [cited 2023 July 13]. Available from: https://emergency.cdc.gov/han/2020/han00432.asp.
12. Dufort EM, Koumans EH, Chow EJ, Rosenthal EM, Muse A, Rowlands J, et al. Multisystem inflammatory syndrome in children in New York state. N Engl J Med. 2020; 383:347–58.
13. Capone CA, Subramony A, Sweberg T, Schneider J, Shah S, Rubin L, et al. Characteristics, cardiac involvement, and outcomes of multisystem inflammatory syndrome of childhood associated with severe acute respiratory syndrome coronavirus 2 infection. J Pediatr. 2020; 224:141–5.
14. Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA. 2020; 324:259–69.
15. Jonat B, Gorelik M, Boneparth A, Geneslaw AS, Zachariah P, Shah A, et al. Multisystem inflammatory syndrome in children associated with coronavirus disease 2019 in a children’s hospital in New York city: patient characteristics and an institutional protocol for evaluation, management, and follow-up. Pediatr Crit Care Med. 2021; 22:e178–91.
16. Belhadjer Z, Auriau J, Méot M, Oualha M, Renolleau S, Houyel L, et al. Addition of corticosteroids to immunoglobulins is associated with recovery of cardiac function in multi-inflammatory syndrome in children. Circulation. 2020; 142:2282–4.
17. Hoste L, Van Paemel R, Haerynck F. Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. Eur J Pediatr. 2021; 180:2019–34.
Full Text Links
  • PEMJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr