Clin Exp Vaccine Res.
2023 Jul;12(3):232-239. 10.7774/cevr.2023.12.3.232.
Immunogenic characterization of AlPO 4 adsorbed Td vaccine and liposome-mediated Td vaccine
- Affiliations
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- 1AL Shifa College of Pharmacy, Perinthalmanna, India.
- 2Department of Pharmaceutics, AL Shifa College of Pharmacy, Perinthalmanna, India.
- 3Pharmacy College, University of Khartoum, Khartoum, Sudan.
- 4Microbiology Department, Sanimed International Lab and Management LLC, Abu Dhabi, United Arab Emirates.
- 5Deparment of Microbiology, Faculty of Veterinary Medicine, University of Khartoum, Khartoum, Sudan.
- 6Department of Biochemistry, University of Veterinary Medicine Hannover, Hanover, Germany.
- 7Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Hanover, Germany.
- KMID: 2545220
- DOI: http://doi.org/10.7774/cevr.2023.12.3.232
Abstract
- Purpose
The purpose of this study was to compare the antigenic potency and stability of tetanus and diphtheria (Td) vaccines when combined with aluminum phosphate (AlPO 4) and liposome adjuvants.
Materials and Methods
In vitro and in vivo analyses were conducted using the single radial immunodiffusion method and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The Td vaccines were prepared with AlPO 4 adsorption and liposome-mediated delivery, and protein antigens were characterized using these methods.
Results
The results revealed that the liposome-mediated Td vaccines exhibited higher immunogenicity compared to the AlP 4-adsorbed Td vaccines. Additionally, the liposome-mediated Td vaccines demonstrated higher stability as native antigens.
Conclusion
This study highlights the importance of utilizing liposome adjuvants in vaccine development. The liposome-mediated Td vaccines showed enhanced immunogenicity and stability, making them a promising approach for improving vaccine efficacy. Understanding and optimizing adjuvant strategies can contribute to the development of effective vaccines against various diseases.
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