Ann Surg Treat Res.  2023 Aug;105(2):63-68. 10.4174/astr.2023.105.2.63.

Surgical management for elderly patients with pancreatic cancer

Affiliations
  • 1Department of Surgery, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea

Abstract

Pancreatic cancer, one of the diseases of the elderly, has dismal prognosis, demanding major surgery with high risk and life quality problems, especially in the elderly. Therefore, treatment selection, whether or not to undergo surgery, preoperative risk assessment, and perioperative management of the elderly are becoming critical issues. Although the elderly are expected to have higher morbidity and mortality and lower long-term survival outcomes, surgery is becoming safer over time. Appropriate surgical indication selection, patient-centered decision-making, adequate prehabilitation and postoperative geriatric care are expected to improve surgical outcomes in the elderly. Surgeons must have the concept of geriatric care, and efforts based on institutional systems and academic societies are required. If well selected and prepared, the same surgical principle as non-elderly patients can be applied to elderly patients. In this paper, the surgical treatment of elderly patients with pancreatic cancer is reviewed.

Keyword

Elderly; Geriatric assessment; Pancreatectomy; Pancreatic cancer

Figure

  • Fig. 1 Preoperative risk assessment. ASA, American Society of Anesthesiology; ECOG, Eastern Cooperative Oncology Group; POSSIUM, Physiologic and Operative Severity Score for the enumeration of Mortality and Morbidity; CSHA, The Canadian Study of Health and Aging; CFS, clinical frailty scale; MSKFI, Memorial Sloan Kettering frailty index; SMI, Skeletal Muscle Index; GNRI, Geriatric Nutritional Risk Index; VES-13, The Vulnerable Elders Survey; E-PASS, Estimation of Physiologic Ability and Surgical Stress.

  • Fig. 2 Risk scoring/calculating systems, general and specific for pancreatectomy.

  • Fig. 3 Postoperative geriatric care that needs a multidisciplinary approach.


Reference

1. Population Division, Department of Economic and Social Affairs, United Nations. World population prospects: the 2008 revision. Volume II. Sex and age distribution of the world population. United Nations Publication;2009. Available from: https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/files/documents/2020/Jan/un_2008_world_population_prospects-2008_revision_volume-ii.pdf .
2. Kang MJ, Lim J, Han SS, Park HM, Park SJ, Won YJ, et al. First course of treatment and prognosis of exocrine pancreatic cancer in Korea from 2006 to 2017. Cancer Res Treat. 2022; 54:208–217. PMID: 34030432.
Article
3. Riall TS, Reddy DM, Nealon WH, Goodwin JS. The effect of age on short-term outcomes after pancreatic resection: a population-based study. Ann Surg. 2008; 248:459–467. PMID: 18791366.
4. Finlayson E, Fan Z, Birkmeyer JD. Outcomes in octogenarians undergoing high-risk cancer operation: a national study. J Am Coll Surg. 2007; 205:729–734. PMID: 18035254.
Article
5. van der Geest LG, Besselink MG, van Gestel YR, Busch OR, de Hingh IH, de Jong KP, et al. Pancreatic cancer surgery in elderly patients: balancing between short-term harm and long-term benefit: a population-based study in the Netherlands. Acta Oncol. 2016; 55:278–285. PMID: 26552841.
Article
6. Wang H, Liu J, Xia G, Lei S, Huang X, Huang X. Survival of pancreatic cancer patients is negatively correlated with age at diagnosis: a population-based retrospective study. Sci Rep. 2020; 10:7048. PMID: 32341400.
Article
7. Park HM, Park SJ, Han SS, Kim SH. Surgery for elderly patients with resectable pancreatic cancer, a comparison with non-surgical treatments: a retrospective study outcomes of resectable pancreatic cancer. BMC Cancer. 2019; 19:1090. PMID: 31718565.
Article
8. Satoi S, Yamamoto T, Uchida K, Fujii T, Kin T, Hirano S, et al. Optimal treatment for octogenarians with resectable and borderline resectable pancreatic ductal adenocarcinoma: a multicenter retrospective study. Pancreas. 2020; 49:837–844. PMID: 32590619.
Article
9. Kang JS, Kim H, Kim JR, Han Y, Kim E, Byun Y, et al. Short- and long-term outcomes of pancreaticoduodenectomy in elderly patients with periampullary cancer. Ann Surg Treat Res. 2020; 98:7–14. PMID: 31909045.
Article
10. Tan E, Song J, Lam S, D’Souza M, Crawford M, Sandroussi C. Postoperative outcomes in elderly patients undergoing pancreatic resection for pancreatic adenocarcinoma: a systematic review and meta-analysis. Int J Surg. 2019; 72:59–68. PMID: 31580919.
Article
11. Meltzer RS, Kooby DA, Switchenko JM, Datta J, Carpizo DR, Maithel SK, et al. Does major pancreatic surgery have utility in nonagenarians with pancreas cancer? Ann Surg Oncol. 2021; 28:2265–2272. PMID: 33141373.
Article
12. Wildiers H, Heeren P, Puts M, Topinkova E, Janssen-Heijnen ML, Extermann M, et al. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol. 2014; 32:2595–2603. PMID: 25071125.
Article
13. American College of Surgeons (ACS). ACS NSQIP Surgical risk calculator [Internet]. ACS National Surgical Quality Improvement Program;c2007-2023. cited 2022 Dec 1. Available from: https://riskcalculator.facs.org/RiskCalculator/PatientInfo.jsp .
14. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982; 5:649–655. PMID: 7165009.
Article
15. Karnofsky DA, Abelmann WH, Craver LF, Burchenal JH. The use of the nitrogen mustards in the palliative treatment of carcinoma: with particular reference to bronchogenic carcinoma. Cancer. 1948; 1:634–656.
Article
16. Copeland GP, Jones D, Walters M. POSSUM: a scoring system for surgical audit. Br J Surg. 1991; 78:355–360. PMID: 2021856.
Article
17. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005; 173:489–495. PMID: 16129869.
Article
18. Shahrokni A, Tin A, Alexander K, Sarraf S, Afonso A, Filippova O, et al. Development and evaluation of a new frailty index for older surgical patients with cancer. JAMA Netw Open. 2019; 2:e193545. PMID: 31074814.
Article
19. Kashani KB, Frazee EN, Kukrálová L, Sarvottam K, Herasevich V, Young PM, et al. Evaluating muscle mass by using markers of kidney function: development of the sarcopenia index. Crit Care Med. 2017; 45:e23–e29. PMID: 27611976.
Article
20. Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002; 50:889–896. PMID: 12028177.
Article
21. Bouillanne O, Morineau G, Dupont C, Coulombel I, Vincent JP, Nicolis I, et al. Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients. Am J Clin Nutr. 2005; 82:777–783. PMID: 16210706.
Article
22. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40:373–383. PMID: 3558716.
Article
23. Piccirillo JF, Creech CM, Zequeira R, Anderson S, Johnston AS. Inclusion of comorbidity into oncology data registries. J Regist Manag. 1999; 26:66–70.
24. van Walraven C, Austin PC, Jennings A, Quan H, Forster AJ. A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Med Care. 2009; 47:626–633. PMID: 19433995.
Article
25. Saliba D, Orlando M, Wenger NS, Hays RD, Rubenstein LZ. Identifying a short functional disability screen for older persons. J Gerontol A Biol Sci Med Sci. 2000; 55:M750–M756. PMID: 11129398.
Article
26. Haga Y, Ikei S, Ogawa M. Estimation of Physiologic Ability and Surgical Stress (E-PASS) as a new prediction scoring system for postoperative morbidity and mortality following elective gastrointestinal surgery. Surg Today. 1999; 29:219–225. PMID: 10192731.
Article
27. Evidencio Medical Decision Support. Risk of complications in patients following pancreaticoduodenectomy [Internet]. Evidencio Community;2018. cited 2022 Dec 1. Available from: https://www.evidencio.com/models/show/1198 .
28. Gleeson EM, Shaikh MF, Shewokis PA, Clarke JR, Meyers WC, Pitt HA, et al. WHipple-ABACUS, a simple, validated risk score for 30-day mortality after pancreaticoduodenectomy developed using the ACS-NSQIP database. Surgery. 2016; 160:1279–1287. PMID: 27544541.
Article
29. Uzunoglu FG, Reeh M, Vettorazzi E, Ruschke T, Hannah P, Nentwich MF, et al. Preoperative Pancreatic Resection (PREPARE) score: a prospective multicenter-based morbidity risk score. Ann Surg. 2014; 260:857–864. PMID: 25243549.
30. Venkat R, Puhan MA, Schulick RD, Cameron JL, Eckhauser FE, Choti MA, et al. Predicting the risk of perioperative mor tal it y in pat ients undergoing pancreaticoduodenectomy: a novel scoring system. Arch Surg. 2011; 146:1277–1284. PMID: 22106320.
Article
31. Winer A, Dotan E. Treatment paradigms for older adults with pancreatic cancer: a nuanced approach. Curr Treat Options Oncol. 2021; 22:104. PMID: 34596801.
Article
32. Kondo N, Uemura K, Nakagawa N, Okada K, Seo S, Takahashi S, et al. Reappraisal of the validity of surgery for patients with pancreatic cancer aged 80 years or older stratified by resectability status. J Hepatobiliary Pancreat Sci. 2020; 27:64–74. PMID: 31602815.
Article
33. Sho M, Murakami Y, Kawai M, Motoi F, Satoi S, Matsumoto I, et al. Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study. J Hepatobiliary Pancreat Sci. 2016; 23:188–197. PMID: 26763744.
Article
34. Weniger M, Moir J, Damm M, Maggino L, Kordes M, Rosendahl J, et al. Neoadjuvant therapy in elderly patients receiving FOLFIRINOX or gemcitabine/nab-paclitaxel for borderline resectable or locally advanced pancreatic cancer is feasible and lead to a similar oncological outcome compared to non-aged patients: results of the RESPECT-Study. Surg Oncol. 2020; 35:285–297. PMID: 32949968.
Article
35. Rieser CJ, Zenati M, Narayanan S, Bahary N, Lee KK, Paniccia A, et al. Optimal management of resectable pancreatic head cancer in the elderly patient: does neoadjuvant therapy offer a survival benefit? Ann Surg Oncol. 2021; 28:6264–6272. PMID: 33748894.
Article
36. Rieser CJ, Narayanan S, Bahary N, Bartlett DL, Lee KK, Paniccia A, et al. Optimal management of patients with operable pancreatic head cancer: a Markov decision analysis. J Surg Oncol. 2021; 124:801–809. PMID: 34231222.
Article
37. Cooper AB, Holmes HM, des Bordes JK, Fogelman D, Parker NH, Lee JE, et al. Role of neoadjuvant therapy in the multimodality treatment of older patients with pancreatic cancer. J Am Coll Surg. 2014; 219:111–120. PMID: 24856952.
Article
38. Chesney TR, Schwarze ML. Patient-centered surgical decision making. Rosenthal RA, Zenilman ME, Katlic MR, editors. Principles and practice of geriatric surgery. Springer International Publishing;2020. p. 81–93.
39. Zhang W, Huang Z, Zhang J, Che X. Effect of laparoscopic pancreaticoduodenectomy in elderly people: a meta-analysis. Pancreas. 2021; 50:1154–1162. PMID: 34714278.
Article
40. Zhu J, Wang G, Du P, He J, Li Y. Minimally invasive pancreaticoduodenectomy in elderly patients: systematic review and meta-analysis. World J Surg. 2021; 45:1186–1201. PMID: 33458781.
Article
41. Kanda M, Fujii T, Suenaga M, Takami H, Inokawa Y, Yamada S, et al. Pancreatoduodenectomy with portal vein resection is feasible and potentially beneficial for elderly patients with pancreatic cancer. Pancreas. 2014; 43:951–958. PMID: 24717827.
Article
42. Fang JZ, Lu CD, Wu SD, Huang J, Zhou J. Portal vein/superior mesenteric vein resection in pancreatic cancer treatment in the elderly. Medicine (Baltimore). 2017; 96:e7335. PMID: 28682880.
Article
43. Jegatheeswaran S, Baltatzis M, Jamdar S, Siriwardena AK. Superior mesenteric artery (SMA) resection during pancreatectomy for malignant disease of the pancreas: a systematic review. HPB (Oxford). 2017; 19:483–490. PMID: 28410913.
Article
44. Wang X, Dong Y, Jin J, Liu Q, Zhan Q, Chen H, et al. Efficacy of modified Appleby surgery: a benefit for elderly patients? J Surg Res. 2015; 194:83–90. PMID: 25311939.
Article
45. Melloul E, Lassen K, Roulin D, Grass F, Perinel J, Adham M, et al. Guidelines for perioperative care for pancreatoduodenectomy: enhanced recovery after surgery (ERAS) recommendations 2019. World J Surg. 2020; 44:2056–2084. PMID: 32161987.
Article
46. Ji HB, Zhu WT, Wei Q, Wang XX, Wang HB, Chen QP. Impact of enhanced recovery after surgery programs on pancreatic surgery: a meta-analysis. World J Gastroenterol. 2018; 24:1666–1678. PMID: 29686474.
47. Raza SS, Nutu OA, Powell-Brett S, Carvalheiro Boteon A, Hodson J, Abradelo M, et al. Impact of an enhanced recovery after surgery protocol on short-term outcomes in elderly patients undergoing pancreaticoduodenectomy. HPB (Oxford). 2022; 24:1720–1728. PMID: 35643908.
48. Bongers BC, Dejong CH, den Dulk M. Enhanced recovery after surgery programmes in older patients undergoing hepatopancreatobiliary surgery: what benefits might prehabilitation have? Eur J Surg Oncol. 2021; 47(3 Pt A):551–559. PMID: 32253075.
49. McDonald SR, Heflin MT, Whitson HE, Dalton TO, Lidsky ME, Liu P, et al. Association of integrated care coordination with postsurgical outcomes in high-risk older adults: the Perioperative Optimization of Senior Health (POSH) Initiative. JAMA Surg. 2018; 153:454–462. PMID: 29299599.
Article
50. Talarico L, Chen G, Pazdur R. Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol. 2004; 22:4626–4631. PMID: 15542812.
Article
51. Okusaka T, Nakamura M, Yoshida M, Kitano M, Uesaka K, Ito Y, et al. Clinical practice guidelines for pancreatic cancer 2019 from the Japan Pancreas Society: a synopsis. Pancreas. 2020; 49:326–335. PMID: 32132516.
Article
52. Backen A, Lamarca A, Hubner RA, McNamara MG, Valle JW. HPB cancers in older patients: inclusion of older/senior patients in clinical trials. Eur J Surg Oncol. 2021; 47(3 Pt A):597–602. PMID: 33298342.
Article
Full Text Links
  • ASTR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr