Korean J Gastroenterol.  2023 Jul;82(1):30-34. 10.4166/kjg.2023.058.

Phlebosclerotic Colitis in a Healthy Young Female with Long-term Herbal Medicine Use

Affiliations
  • 1Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea

Abstract

Phlebosclerotic colitis is a rare form of intestinal ischemia. It is caused by calcified peripheral mesenteric veins and a thickened colonic wall. These characteristic findings can be identified on CT and colonoscopy. A 37-year-old female with a history of long-term herbal medicine use presented with acute lower abdominal pain and vomiting of sudden onset. Colonoscopic findings showed dark-blue discolored edematous mucosa and multiple ulcers from the ascending colon to the sigmoid colon. Abdominal CT findings showed diffuse thickening of the colonic wall and calcifications of the peripheral mesenteric veins from the ascending colon to the sigmoid colon. Based on these findings, the patient was diagnosed with phlebosclerotic colitis. We report this rare case of phlebosclerotic colitis in a healthy young female patient with a history of long-term herbal medicine use and include a review of the relevant literature.

Keyword

Female; Ischemic colitis; Herbal medicine

Figure

  • Fig. 1 Plain abdominal radiographic finding showing multiple linear calcifications (arrows) in the right lower quadrant, left lower quadrant, and epigastric area.

  • Fig. 2 Abdominal CT findings (A, B) showing diffuse thickening of the colonic wall from the ascending colon to the sigmoid colon and calcifications of the peripheral mesenteric veins.

  • Fig. 3 Colonoscopic findings (A-C) showing dark-blue discolored edematous mucosa and ulcers from the ascending colon to the sigmoid colon. (A) The ascending colon, (B) The descending colon, and (C) The sigmoid colon.

  • Fig. 4 Follow-up colonoscopic findings (A-C) showing lesion improvement, with regressed multiple erosions, ulcers, and mucosal friability, and the remaining mild dark-blue discolored mucosa. (A) The ascending colon, (B) The descending colon, and (C) The sigmoid colon.


Cited by  1 articles

Extensive Phlebosclerotic Colitis Involving the Entire Colorectum
Seung Min Hong, Geun Am Song, Dong Hoon Baek
Korean J Gastroenterol. 2024;83(3):127-130.    doi: 10.4166/kjg.2024.017.


Reference

1. Yao T, Iwashita A, Hoashi T, et al. 2000; Phlebosclerotic colitis: value of radiography in diagnosis--report of three cases. Radiology. 214:188–192. DOI: 10.1148/radiology.214.1.r00ja01188. PMID: 10644121.
2. Theodoropoulou A, Koutroubakis IE. 2008; Ischemic colitis: clinical practice in diagnosis and treatment. World J Gastroenterol. 14:7302–7308. DOI: 10.3748/wjg.14.7302. PMID: 19109863. PMCID: PMC2778113.
3. Brandt LJ, Boley SJ. 2000; AGA technical review on intestinal ischemia. American Gastrointestinal Association. Gastroenterology. 118:954–968. DOI: 10.1016/S0016-5085(00)70183-1. PMID: 10784596.
4. Choi JM, Lee KN, Kim HS, et al. 2014; Idiopathic phlebosclerotic colitis: a rare entity of chronic ischemic colitis. Korean J Gastroenterol. 63:183–186. DOI: 10.4166/kjg.2014.63.3.183. PMID: 24651592.
5. Kang HY, Noh R, Kim SM, Shin HD, Yun SY, Song IH. 2009; Phlebosclerotic colitis in a cirrhotic patient with portal hypertension: the first case in Korea. J Korean Med Sci. 24:1195–1199. DOI: 10.3346/jkms.2009.24.6.1195. PMID: 19949682. PMCID: PMC2775874.
6. Song JH, Kim JI, Jung JH, et al. 2012; [A case of phlebosclerotic colitis in a hemodialysis patient]. Korean J Gastroenterol. 59:40–43. Korean. DOI: 10.4166/kjg.2012.59.1.40. PMID: 22289953.
7. Chang KM. 2007; New histologic findings in idiopathic mesenteric phlebosclerosis: clues to its pathogenesis and etiology--probably ingested toxic agent-related. J Chin Med Assoc. 70:227–235. DOI: 10.1016/S1726-4901(09)70364-8. PMID: 17591581.
8. Yeh HJ, Lin PY, Kao WY, Kun CH, Chang CC. 2018; Idiopathic mesenteric phlebosclerosis associated with long-term use of Chinese herbal medicine. Turk J Gastroenterol. 29:140–142. DOI: 10.5152/tjg.2018.17072. PMID: 29391325. PMCID: PMC6322607.
9. Hiramatsu K, Sakata H, Horita Y, et al. 2012; Mesenteric phlebosclerosis associated with long-term oral intake of geniposide, an ingredient of herbal medicine. Aliment Pharmacol Ther. 36:575–586. DOI: 10.1111/j.1365-2036.2012.05221.x. PMID: 22817400.
10. Guo F, Zhou YF, Zhang F, Yuan F, Yuan YZ, Yao WY. 2014; Idiopathic mesenteric phlebosclerosis associated with long-term use of medical liquor: two case reports and literature review. World J Gastroenterol. 20:5561–5566. DOI: 10.3748/wjg.v20.i18.5561. PMID: 24833888. PMCID: PMC4017073.
11. Iwashita A, Yao T, Schlemper RJ, et al. 2003; Mesenteric phlebosclerosis: a new disease entity causing ischemic colitis. Dis Colon Rectum. 46:209–220. DOI: 10.1007/s10350-004-6526-0.
12. Minh ND, Hung ND, Huyen PT, et al. 2022; Phlebosclerotic colitis with long-term herbal medicine use. Radiol Case Rep. 17:1696–1701. DOI: 10.1016/j.radcr.2022.02.069. PMID: 35342497. PMCID: PMC8942791.
13. Park JK, Sung YH, Cho SY, Oh CY, An SH. 2015; Phlebosclerotic colitis in a healthy young woman. Clin Endosc. 48:447–451. DOI: 10.5946/ce.2015.48.5.447. PMID: 26473132. PMCID: PMC4604287.
14. Oshitani N, Matsumura Y, Kono M, et al. 2002; Asymptomatic chronic intestinal ischemia caused by idiopathic phlebosclerosis of mesenteric vein. Dig Dis Sci. 47:2711–2714. DOI: 10.1023/A:1021090113274. PMID: 12498290.
15. Kato T, Miyazaki K, Nakamura T, Tan KY, Chiba T, Konishi F. 2010; Perforated phlebosclerotic colitis--description of a case and review of this condition. Colorectal Dis. 12:149–151. DOI: 10.1111/j.1463-1318.2008.01726.x. PMID: 19175648.
16. Chen MT, Yu SL, Yang TH. 2010; A case of phlebosclerotic colitis with involvement of the entire colon. Chang Gung Med J. 33:581–585.
17. Hu P, Deng L. 2013; Phlebosclerotic colitis: three cases and literature review. Abdom Imaging. 38:1220–1224. DOI: 10.1007/s00261-013-0001-0. PMID: 23589075.
18. Yu CJ, Wang HH, Chou JW, et al. 2009; Phlebosclerotic colitis with nonsurgical treatment. Int J Colorectal Dis. 24:1241–1242. DOI: 10.1007/s00384-009-0707-1. PMID: 19390857.
19. Yoshikawa K, Okahisa T, Kaji M, et al. 2009; Idiopathic phlebosclerosis: an atypical presentation of ischemic colitis treated by laparoscopic colectomy. Surgery. 145:682–684. DOI: 10.1016/j.surg.2008.04.015. PMID: 19486773.
20. Fang YL, Hsu HC, Chou YH, Wu CC, Chou YY. 2014; Phlebosclerotic colitis: A case report and review of the literature. Exp Ther Med. 7:583–586. DOI: 10.3892/etm.2014.1492. PMID: 24520249. PMCID: PMC3919902.
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