Immune Netw.
2023 Feb;23(1):e11. 10.4110/in.2023.23.e11.
Roles of Virtual Memory T Cells in Diseases
- Affiliations
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- 1Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06974, Korea
- 2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea
- 3The Center for Epidemic Preparedness, KAIST Institute, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea
- KMID: 2544655
- DOI: http://doi.org/10.4110/in.2023.23.e11
Abstract
- Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a “memory-like” T-cell population, termed virtual memory T (T VM ) cells that acquire a memory phenotype in the absence of foreign Ag, has been reported. Although, like innate cells, T VM cells reportedly play a role in first-line defense to bacterial or viral infections, their protective or pathological roles in immune-related diseases are largely unknown. In this review, we discuss the current understanding of T VM cells, focusing on their distinct characteristics, immunological properties, and roles in various immune-related diseases, such as infections and cancers.
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