Endocrinol Metab.  2023 Jun;38(3):305-314. 10.3803/EnM.2023.1690.

Effects of Weight Loss and Interaction with Physical Activity on Risks of Cardiovascular Outcomes in Individuals with Type 2 Diabetes

• Cardoso CRL
• Leite NC
• Salles GF

• KMID: 2543317
• DOI: http://doi.org/10.3803/EnM.2023.1690

Abstract

Background
This study investigated the effects of weight loss during follow-up on cardiovascular outcomes in a type 2 diabetes cohort and tested interactions with clinical and laboratory variables, particularly physical activity, that could impact the associations.
Methods
Relative weight changes were assessed in 651 individuals with type 2 diabetes and categorized as ≥5% loss, <5% loss, or gain. Associations between weight loss categories and incident cardiovascular outcomes (total cardiovascular events [CVEs], major adverse cardiovascular events [MACEs], and cardiovascular mortality) were assessed using multivariable Cox regression with interaction analyses.
Results
During the initial 2 years, 125 individuals (19.2%) lost ≥5% of their weight, 180 (27.6%) lost <5%, and 346 (53.1%) gained weight. Over a median additional follow-up of 9.3 years, 188 patients had CVEs (150 MACEs) and 106 patients died from cardiovascular causes. Patients with ≥5% weight loss had a significantly lower risk of total CVEs (hazard ratio [HR], 0.52; 95% confidence interval, 0.33 to 0.89; P=0.011) than those who gained weight, but non-significant lower risks of MACEs or cardiovascular deaths. Patients with <5% weight loss had risks similar to those with weight gain. There were interactions between weight loss and physical activity. In active individuals, ≥5% weight loss was associated with significantly lower risks for total CVEs (HR, 0.20; P=0.004) and MACEs (HR, 0.21; P=0.010), whereas in sedentary individuals, no cardiovascular protective effect of weight loss was evidenced.
Conclusion
Weight loss ≥5% may be beneficial for cardiovascular disease prevention, particularly when achieved with regular physical activity, even in high-risk individuals with long-standing type 2 diabetes.

Keyword

Cardiovascular outcomes; Physical activity; Diabetes mellitus, type 2; Weigth loss

Figure

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  Fig. 1. Kaplan-Meier curves of the cumulative incidence of endpoints in patients grouped according to relative body weight changes during the first 2 years of follow-up: G1 is the subgroup that lost ≥5% of weight, G2 lost 0% to <5%, and G3 gained weight. (A) Total cardiovascular events (CVEs), (B) major adverse cardiovascular events (MACEs), and (C) cardiovascular (CV) deaths.

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