Int J Thyroidol.  2023 May;16(1):96-100. 10.11106/ijt.2023.16.1.96.

Application of Nerve Guided Conduits for Recurrent Laryngeal Nerve Regeneration

• Kim JM
• Choi JS

• KMID: 2543012
• DOI: http://doi.org/10.11106/ijt.2023.16.1.96

Abstract

Recurrent laryngeal nerve injury is a common complication of thyroid surgery that can cause communication disorders, aspiration, and swallowing difficulties. Despite extensive knowledge of the pathology and regeneration mechanisms of recurrent laryngeal nerve injury, reliable treatments that guarantee complete functional recovery are insufficient. Currently, nerve auto-grafting is the gold standard for the treatment of recurrent laryngeal nerve damage. However, due to the limitations of nerve auto-grafting, such as donor site morbidity and limited supply, alternative treatment methods are necessary in this field. Nerve guide conduits are being increasingly considered as potential alternatives to nerve auto-grafts in the treatment of recurrent laryngeal nerve damage. In recent years, researchers have attempted to develop structurally stable and biocompatible nerve guide conduits using tissue engineering technology, including internal and external structural changes, the development of biocompatible materials, and drug release. This article reviews research papers on the development of functionally developed nerve-guided conduits for recurrent laryngeal nerve regeneration.

Keyword

Recurrent laryngeal nerve injury; Nerve guided conduit; Nerve regeneration

Reference

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