J Korean Med Sci.
2023 May;38(17):e135. 10.3346/jkms.2023.38.e135.
Injectable Poloxamer Hydrogel Formulations for Intratympanic Delivery of Dexamethasone
- Affiliations
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- 1Department of Polymer Science and Engineering, Chungnam National University, Daejeon, Korea
- 2Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon, Korea
- 3Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Korea
- 4Brain Research Institute, College of Medicine, Chungnam National University, Daejeon, Korea
- KMID: 2542023
- DOI: http://doi.org/10.3346/jkms.2023.38.e135
Abstract
- Background
In this study, we prepared and evaluated an injectable poloxamer (P407) hydrogel formulation for intratympanic (IT) delivery of dexamethasone (DEX).
Methods
DEX-loaded P407 hydrogels were characterized in terms of thermogelation, drug loading capacities, particle size, and drug release. The in vivo toxicity and drug absorption of the DEX-loaded P407 formulation after IT injection were evaluated using an animal model by performing histopathological analysis and drug concentration measurements.
Results
The P407 hydrogel effectively solubilized hydrophobic DEX and demonstrated a sustained release compared to the hydrophilic DEX formulation. The in vivo study showed that the hydrogel formulation delivered considerable drug concentrations to the inner ear and displayed a favorable safety profile without apparent cytotoxicity or inflammation.
Conclusion
P407 hydrogel can be useful as an injectable inner ear delivery formulation for hydrophobic drugs due to their biocompatibility, drug-solubilizing capacity, thermogelation, and controlled release.
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