Blood Res.
2023 Apr;58(S1):46-51. 10.5045/br.2023.2023008.
Current status of red blood cell manufacturing in 3D culture and bioreactors
- Affiliations
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- 1Department R&D, ArtBlood Inc., Seoul, Korea
- 2Department of Translational Medicine, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea
- 3Department of Laboratory Medicine, College of Medicine, Hanyang University, Seoul, Korea
- KMID: 2541982
- DOI: http://doi.org/10.5045/br.2023.2023008
Abstract
- Owing to donor-related issues, blood shortages and transfusion-related adverse reactions have become global issues of grave concern. In vitro manufactured red blood cells (RBCs) are promising substitutes for blood donation. In the United Kingdom, a clinical trial for allogeneic mini transfusion of cultured RBCs derived from primary hematopoietic stem cells has recently begun. However, current production quantities are limited and need improved before clinical use. New methods to enhance manufacturing efficiencies have been explored, including different cell sources, bioreactors, and 3-dimensional (3D) materials; however, further research is required. In this review, we discuss various cell sources for blood cell production, recent advances in bioreactor manufacturing processes, and the clinical applications of cultured blood.
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