Precis Future Med.  2019 Mar;3(1):19-23. 10.23838/pfm.2018.00128.

Bioreactor systems are essentially required for stem cell bioprocessing

  • 13D Stem Cell Bioprocessing Laboratory, Department of Mechatronics, Incheon National University, Incheon, Korea.
  • 2Smart Healthcare & Device Research Center, Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 3Department of Chemistry, Chung-Ang University, Seoul, Korea.


As stem cell technologies have rapidly advanced, the stem cell therapy market has been forecast to reach hundreds of millions of USD in market value within the next 5 years. Regulatory frameworks throughout the stem cell market have been concurrently established, which will encourage the advent of a variety of stem cell products in our society. Given the circumstances, stem cell bioprocessing has emerged as one of the most critical fields of research to address a number of issues that currently exist in manufacturing clinical-grade stem cells at an industrial scale. Highly specialized bioreactor designs are at the center of essentially required technologies in the field of stem cell bioprocessing, which ultimately aim for automated, standardized, traceable, cost-effective, safe, and regulatory-compliant manufacture of stem cell-based products. In this review, recently developed bioreactor designs to introduce important regulatory factors to three-dimensional stem cell culture are exemplified, and prerequisites for the ideal bioreactor systems for stem cell bioprocessing are discussed.


Bioreactors; Cell culture techniques; Clinical grade stem cells; Industrial scale; Stem cell bioprocessing

MeSH Terms

Cell Culture Techniques
Stem Cells*
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