J Breast Cancer.
2023 Apr;26(2):168-185. 10.4048/jbc.2023.26.e5.
The Cancer/Testis Antigen CT45A1 Promotes Transcription of Oncogenic Sulfatase-2 Gene in Breast Cancer Cells and Is Sensible Targets for Cancer Therapy
- Affiliations
-
- 1Department of Pathophysiology, School of Medicine, Nantong University, Nantong, P.R. China
- 2Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, Soochow University, Suzhou, P.R. China
- 3State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, P.R. China
- KMID: 2541766
- DOI: http://doi.org/10.4048/jbc.2023.26.e5
Abstract
- Conclusion: Overexpression of CT45A1 is associated with poor prognosis in patients with BRCA. CT45A1 promotes SULF2 overexpression by activating the promoter and interacting with SP1. Additionally, SP1 and SULF2 inhibitors suppress breast cancer cell migration, invasion, and tumorigenesis. Our findings provide new insight into the mechanisms of breast cancer metastasis and highlight CT45A1 and SULF2 as sensible targets for developing novel therapeutics against metastatic breast cancer.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Applicability of Genes of Cancer-associated Testis Antigens in Diagnosis of Cancer
- OCT4 Expression Enhances Features of Cancer Stem Cells in a Mouse Model of Breast Cancer
- New Findings on Breast Cancer Stem Cells: A Review
- Roles of Oncogenic Long Non-coding RNAs in Cancer Development
- Current Approaches in Development of Immunotherapeutic Vaccines for Breast Cancer
