Acute Crit Care.  2023 Feb;38(1):1-7. 10.4266/acc.2023.00381.

Extracorporeal circulation models in small animals: beyond the limits of preclinical research

• Kayumov M
• Habimana R
• Kim D
• Obiweluozor FO
• Jeong IS
• Cho HJ

• KMID: 2540309
• DOI: http://doi.org/10.4266/acc.2023.00381

Abstract

Extracorporeal membrane oxygenation (ECMO) use has remarkably increased in recent years. Although ECMO has become essential for patients with refractory cardiac and respiratory failure, extracorporeal circulation (ECC) is associated with significant complications. Small-animal models of ECC have been developed and widely used to better understand ECC-induced pathophysiology. This review article summarizes the development of small-animal ECC models, including the animal species, circuit configuration, priming, perioperative procedures, cannulation, and future perspectives of small-animal ECMO models.

Keyword

cardiopulmonary bypass; extracorporeal circulation; extracorporeal membrane oxygenation; review; experimental research

Figure

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  Figure 1. Common experimental extracorporeal membrane oxygenation (ECMO) models. Created with BioRender.com.

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