Korean J Anesthesiol.  1988 Oct;21(5):764-771. 10.4097/kjae.1988.21.5.764.

The Change of Platelet Count and Plasma Fibrinogen Level during and after Extracorporeal Circulation

Affiliations
  • 1Department of Anesthesiology, College of Medicine, Yeungnam University, Taegu, Korea.

Abstract

In order to evaluate causes and the effective treatment of postoperative bleeding after open heart surgery, we measured platelet count and plasma fibrinogen levels before, during a 30 and 60-minute, and after a 30, 60 and 90-minute extracorporeal circulation in 5 patients perfused by a bubble and membrane oxygenator, respectively. The results were as follows: 1) The platelet count was reduced significantly by 57.2+/-3.04% during a 30-minute extracorporeal circulation using the bubble oxygenator and by 43.8+/-0.84% using the membrane oxygenator, and these levels were maintained throughout the extracorporeal circulation. 2) The platelet count after a 90-minute extracorporeal circulation increased significantly compared with after a 30-minute extracorporeal circulation (p<0.05) and these effects were more prominent using the bubble oxygenator (p<0.025). 3) The plasma fibrinogen level was reduced by 28.6+/-7.50% during a 30-minute extracorporeal circulation using the bubble oxygenator and by 33.6+/-5.77% using the membrane oxygenator, and these levels were maintained throughout the extracorporeal circulation. 4) The plasma fibrinogen level after a 90-minute extracorporeal circulation increased significantly compared with after a 30-minute extracorporeal circulation (p<0.05).

Keyword

Open heart surgery; Extracorporeal circulation; Platelet; Fibrinogen

MeSH Terms

Blood Platelets*
Extracorporeal Circulation*
Fibrinogen*
Hemorrhage
Humans
Oxygen
Oxygenators
Oxygenators, Membrane
Plasma*
Platelet Count*
Thoracic Surgery
Fibrinogen
Oxygen
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