Clin Psychopharmacol Neurosci.
2023 Feb;21(1):10-18. 10.9758/cpn.2023.21.1.10.
The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)
- Liu ST
1 - Lin SC2
- Chang JPC3,4,5
- Yang KJ3,5
- Chu CS6
- Yang CC7
- Liang CS8
- Sun CF9
- Wang SC10,11
- Satyanarayanan SK3
- Su KP2,3,5
- Affiliations
-
- 1Division of Child and Adolescent Psychiatry & Division of Developmental and Behavioral Pediatrics, China Medical University Children’s Hospital, Taichung
- 2An-Nan Hospital, China Medical University, Tainan
- 3Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan
- 4Division of Child Psychiatry, Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan.
- 5Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan.
- 6Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
- 7Department of Psychiatry, Taoyuan Psychiatric Center, Taoyuan City, Taiwan.
- 8Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
- 9Department of Psychiatry and Behavioral Medicine, Virginia Tech Carilion Clinic School of Medicine, Roanoke, VA, USA.
- 10Department of Psychiatry, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
- 11Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
- KMID: 2539646
- DOI: http://doi.org/10.9758/cpn.2023.21.1.10
Abstract
- There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.
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