J Surg Ultrasound.  2022 May;9(1):18-21. 10.46268/jsu.2022.9.1.18.

Differences of Tumor Size Measured by Ultrasonography and Magnetic Resonance Imaging Compared to Pathological Tumor Size in Primary Breast Cancer

• Kim YH
• Kim YS

• KMID: 2536060
• DOI: http://doi.org/10.46268/jsu.2022.9.1.18

Abstract

Background
Preoperative measurement of the tumor size is essential for deciding on a treatment plan for breast cancer. In particular, in a neoadjuvant setting, the treatment plan is based on preoperative clinical staging. This study evaluated the differences in tumor size measured by ultrasonography and magnetic resonance imaging (MRI) compared to the pathological tumor size.
Methods
This study reviewed the electronic medical records of patients with primary breast cancer who underwent surgery between 2014 and 2021. The clinicopathologic data, including ultrasonographic and MRI findings, were collected. Bland-Altman analysis was used to compare the differences in the tumor size between the imaging modalities and pathological tumor size.
Results
The tumor size was underestimated significantly by ultrasonography. On the other hand, there were not significant differences in the correlation.
Conclusion
The preoperative evaluation, including ultrasonography and MRI, helps predict the tumor size accurately in primary breast cancer.

Keyword

Ultrasonography; Magnetic resonance imaging; Breast neoplasm

Figure

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  Fig. 1 Bland Altman Plots illus-trating the size difference between ultrasonography and pathology com-pared to the pathological tumor size.

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  Fig. 2 Bland Altman Plots illus-tra-ting the size difference between MRI and pathology compared to the pathological tumor size.

Reference

1. Guo R, Lu G, Qin B, Fei B. 2018; Ultrasound imaging technologies for breast cancer detection and management: a review. Ultrasound Med Biol. 44:37–70. DOI: 10.1016/j.ultrasmedbio.2017.09.012. PMID: 29107353. PMCID: PMC6169997.

2. Yang WT. 2011; Staging of breast cancer with ultrasound. Semin Ultrasound CT MR. 32:331–41. DOI: 10.1053/j.sult.2011.02.008. PMID: 21782123.

3. Romeo V, Accardo G, Perillo T, Basso L, Garbino N, Nicolai E, et al. 2021; Assessment and prediction of response to neoadjuvant chemotherapy in breast cancer: a comparison of imaging modalities and future perspectives. Cancers (Basel). 13:3521. DOI: 10.3390/cancers13143521. PMID: 34298733. PMCID: PMC8303777.

4. Bosch AM, Kessels AG, Beets GL, Rupa JD, Koster D, van Engelshoven JM, et al. 2003; Preoperative estimation of the pathological breast tumour size by physical examination, mammography and ultrasound: a prospective study on 105 invasive tumours. Eur J Radiol. 48:285–92. DOI: 10.1016/S0720-048X(03)00081-0. PMID: 14652148.

5. Hieken TJ, Harrison J, Herreros J, Velasco JM. 2001; Correlating sonography, mammography, and pathology in the assessment of breast cancer size. Am J Surg. 182:351–4. DOI: 10.1016/S0002-9610(01)00726-7. PMID: 11720669.

6. Shoma A, Moutamed A, Ameen M, Abdelwahab A. 2006; Ultrasound for accurate measurement of invasive breast cancer tumor size. Breast J. 12:252–6. DOI: 10.1111/j.1075-122X.2006.00249.x. PMID: 16684323.

7. Onesti JK, Mangus BE, Helmer SD, Osland JS. 2008; Breast cancer tumor size: correlation between magnetic resonance imaging and pathology measurements. Am J Surg. 196:844–48. discussion 849–50. DOI: 10.1016/j.amjsurg.2008.07.028. PMID: 19095098.

8. Kang SY, Choi EJ, Youn HJ, Jung SH. 2016; Accuracy of preoperative tumor size assessment on ultrasonography and magnetic resonance imaging in breast cancer. J Surg Ultrasound. 3:24–9.

9. Boetes C, Mus RD, Holland R, Barentsz JO, Strijk SP, Wobbes T, et al. 1995; Breast tumors: comparative accuracy of MR imaging relative to mammography and US for demonstrating extent. Radiology. 197:743–7. DOI: 10.1148/radiology.197.3.7480749. PMID: 7480749.

10. Davis PL, Staiger MJ, Harris KB, Ganott MA, Klementaviciene J, McCarty KS Jr, et al. 1996; Breast cancer measurements with magnetic resonance imaging, ultrasonography, and mammography. Breast Cancer Res Treat. 37:1–9. DOI: 10.1007/BF01806626. PMID: 8750522.

11. Wasif N, Garreau J, Terando A, Kirsch D, Mund DF, Giuliano AE. 2009; MRI versus ultrasonography and mammography for preoperative assessment of breast cancer. Am Surg. 75:970–5. DOI: 10.1177/000313480907501024. PMID: 19886147.

12. Pritt B, Ashikaga T, Oppenheimer RG, Weaver DL. 2004; Influence of breast cancer histology on the relationship between ultrasound and pathology tumor size measurements. Mod Pathol. 17:905–10. DOI: 10.1038/modpathol.3800138. PMID: 15105809.