Acute Crit Care.  2022 Aug;37(3):480-481. 10.4266/acc.2022.00556.

De-adoption of oral chlorhexidine for mechanically ventilated patients: get thee to a conclusion

Affiliations
  • 1Department of Cardiothoracic Surgery/Cardiac Anaesthesia and ICU Section, Heart Hospital, Hamad Medical Corporation, Doha, Qatar
  • 2Department of Critical Care Medicine, Beni-Suef University, Beni Suef, Egypt
  • 3Weill Cornell Medical College-Qatar, Doha, Qatar
  • 4Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Qatar


Reference

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2. Klompas M, Speck K, Howell MD, Greene LR, Berenholtz SM. Reappraisal of routine oral care with chlorhexidine gluconate for patients receiving mechanical ventilation: systematic review and meta-analysis. JAMA Intern Med. 2014; 174:751–61.
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3. Dale CM, Rose L, Carbone S, Pinto R, Smith OM, Burry L, et al. Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial. Intensive Care Med. 2021; 47:1295–302.
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4. Bellissimo-Rodrigues WT, Menegueti MG, de Macedo LD, Basile-Filho A, Martinez R, Bellissimo-Rodrigues F. Oral mucositis as a pathway for fatal outcome among critically ill patients exposed to chlorhexidine: post hoc analysis of a randomized clinical trial. Crit Care. 2019; 23:382.
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