Korean J Transplant.  2022 Nov;36(Supple 1):S207. 10.4285/ATW2022.F-3468.

Pancreas transplantation: a 12-year single-center experience at Siriraj Hospital, Thailand

• Mahawithitwong P
• Limsrichamrern S
• Sirivatanauksorn Y
• Kositamongkol P
• Tovikkai C
• Dumronggittigule W
• Sangserestid P
• Assawasirisin C

• KMID: 2535272
• DOI: http://doi.org/10.4285/ATW2022.F-3468

Abstract

Background
Simultaneous pancreas kidney transplantation (SPK) and pancreas after kidney transplantation (PAK) are the best treatment for type I diabetes mellitus (T1DM) with end-stage renal disease (ESRD). Pancreas transplantation alone (PTA) is also an option in selected case of T1DM. However, there were still limited numbers of reports from South-East Asia. Herein, we reported our experience of pancreas transplantation from the largest pancreas transplant center in Thailand.
Methods
We retrospectively reviewed 18 cases of pancreas transplantation at Siriraj Hospital between October 2010 and August 2022. There were 11 males and seven females. Mean age was 38.6±6.9 years (range, 25–52 years). Sixteen (88.9%) patients underwent SPK, and one each underwent PAK and PTA. All of pancreas transplantation was performed with portal-ve-nous and enteric drainage.
Results
Almost all pancreatic grafts were maintained in good renal function and normoglycemia without insulin therapy. There was only one pancreas graft loss due to ruptured arterial graft aneurysm from candida infection in the early postoperative period resulting graft pancreatectomy. There was no rejection of pancreas graft during the follow-up. Three patients died from sudden hypovolemic shock, congestive heart failure and stroke during the follow-up period. The overall survival at 1, 3, 5 and 10 years was 94.4%, 94.4%, 76.3% and 76.3%, respectively.
Conclusions
Since the first successful pancreas transplantation in Thailand since 2010 at Siriraj Hospital, we have continued to provide the pancreas transplant service with good long-term outcome for 12 years. Pancreas transplant is safe and can provide better quality of life in T1DM patients.