Clin Endosc.  2022 Jul;55(4):507-515. 10.5946/ce.2022.035.

Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review

• Reggiani HC
• Pongeluppi ACA
• Ferreira VFMM
• Felix IP
• de Oliveira Campoli PM

• KMID: 2531942
• DOI: http://doi.org/10.5946/ce.2022.035

Abstract

Background/Aims
Metastases of malignant melanoma (MM) are rare and associated with poor prognosis. The objective of this study was to analyze the clinical and endoscopic characteristics of gastric metastases of MM by systematically reviewing cases and case series involving patients diagnosed using upper gastrointestinal endoscopy.
Methods
The PubMed and LILACS databases were searched. Reports containing individual patient data were included. Outcomes such as clinical data, endoscopic findings, treatments, and survival were analyzed.
Results
A total of 88 studies with individual data from 113 patients with gastric metastases of MM were included. The primary sites of MM were the skin (62%), eyes (10%), and mucous membranes (6%). Most patients (56%) had multiple metastases in the stomach, located predominantly in the gastric body (approximately 80%). The overall survival rate at 2 years was 4%. There was a significant reduction in the survival of patients with multiple gastric metastases compared to that of patients with single metastasis (hazard ratio, 0.459; 95% confidence interval, 0.235−0.895; p=0.022).
Conclusions
Gastric metastases of MM have a poor prognosis, especially in patients with multiple implants in the stomach. Additional studies are needed to verify whether ocular and mucosal melanomas are associated with a higher risk of gastric metastases than that of cutaneous melanomas.

Keyword

Melanoma; Neoplasm metastasis; Oesophagogastroduodenoscopy; Stomach neoplasms; Systematic review

Figure

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  Fig. 1. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram of study selection. LILACS, Latin American and Caribbean Health Science Literature.

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  Fig. 2. Among the 88 studies, 80 included one case. The other eight studies were case series. Four studies had two patients each, two studies had three patients, one study had nine patients, and one study had ten patients.

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  Fig. 3. Estimated overall survival by Kaplan-Meier analysis. Patients with multiple gastric metastases were compared to patients with single gastric metastasis. CI, confidence interval. a)Number of patients at risk of survival.

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