Biomol Ther.  2022 Jul;30(4):299-308. 10.4062/biomolther.2021.180.

Strategies for Manipulating T Cells in Cancer Immunotherapy

• Lee HM

• KMID: 2530994
• DOI: http://doi.org/10.4062/biomolther.2021.180

Abstract

T cells are attractive targets for the development of immunotherapy to treat cancer due to their biological features, capacity of cytotoxicity, and antigen-specific binding of receptors. Novel strategies that can modulate T cell functions or receptor reactivity provide effective therapies, including checkpoint inhibitor, bispecific antibody, and adoptive transfer of T cells transduced with tumor antigen-specific receptors. T cell-based therapies have presented successful pre-clinical/clinical outcomes despite their common immune-related adverse effects. Ongoing studies will allow us to advance current T cell therapies and develop innovative personalized T cell therapies. This review summarizes immunotherapeutic approaches with a focus on T cells. Anti-cancer T cell therapies are also discussed regarding their biological perspectives, efficacy, toxicity, challenges, and opportunities.

Keyword

Cancer immunotherapy; Checkpoint inhibitor; Bispecific antibody; Adoptive T cell transfer; Tumor-specific T cells