J Korean Geriatr Psychiatry.  2022 Apr;26(1):18-22. 10.47825/jkgp.2022.26.1.18.

Choroid Plexus and Its Association of Subtypes of Delusion in Patient With Alzheimer’s Disease

Affiliations
  • 1Department of Psychiatry, Bugok National Hospital, Changnyeong, Korea
  • 2Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea
  • 3Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
  • 4Departments of Radiology, Pusan National University School of Medicine, Yangsan, Korea
  • 5Departments of Nuclear Medicine, Pusan National University School of Medicine, Yangsan, Korea
  • 6Departments of Pathology, Pusan National University School of Medicine, Yangsan, Korea

Abstract


Objective
This study examined the volume of choroid plexus across AD without delusion (AD-D), AD with paranoid delusion (AD+PD), and AD with misidentification delusion (AD+MD).
Methods
This is a hospital based cross-sectional study of patients with AD. The main outcome measure is the volume of choroid plexus that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covariance (ANCOVA) was conducted to compare the differences on the volume of choroid plexus across AD-D, AD+PD, and AD+MD after controlling demographics.
Results
There was no volume difference in the both choroid plexus between AD-D and AD+D. However, the volumes of both cho-roid plexus were significantly reduced in AD+MD compared to AD+PD.
Conclusion
Our study demonstrates that AD+MD has significantly reduced volumes of choroid plexus compared to AD+PD. These findings suggest that AD+MD and AD+PD may have different pathophysiological mechanisms related to neuroimmune re-sponses in the choroid plexus.

Keyword

Choroid plexus; Alzheimer’s disease; Misidentification delusion
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