Nat Prod Sci.  2022 Mar;28(1):40-43. 10.20307/nps.2022.28.1.40.

Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton

Affiliations
  • 1Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia
  • 2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya 60231, Indonesia
  • 3Faculty of Applied Sciences, Universiti Teknologi MARA 40450 Shah Alam, Selangor, Malaysia

Abstract

Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, Flemingialineata A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1-3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC 50 value of 11.2 µM.

Keyword

Flemingia lineata; flemilineatins A-B; flavanone; cytotoxicity
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