Maxillofac Plast Reconstr Surg.  2021;43(1):39. 10.1186/s40902-021-00326-2.

The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells

• Lee IS
• Chang JH
• Kim DW
• Kim SG
• Kim TW

• KMID: 2525724
• DOI: http://doi.org/10.1186/s40902-021-00326-2

Abstract

Background
4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol. Method: In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.
Results
In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h).
Conclusion
4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.

Keyword

4-hexylresorcinol; Sirtuin; NAD+