Kosin Med J.  2021 Dec;36(2):109-115. 10.7180/kmj.2021.36.2.109.

The Natural Course of Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease undergoing Hemodialysis

  • 1Department of Internal Medicine, Kosin University College of Medicine, Busan, Republic of Korea
  • 2Department of Radiology, Kosin University College of Medicine, Busan, Republic of Korea
  • 3Department of Internal Medicine, Bong Seng Hospital, Busan, Republic of Korea


The natural course of native kidneys after hemodialysis initiation in patients with autosomal dominant polycystic kidney disease (ADPKD) remains poorly understood.
We measured the total volumes of native kidneys in 12 patients who had at least one enhanced computed tomography (CT) image both before and after initiation of hemodialysis (group 1) and in 18 patients who had no image before dialysis but more than two images after dialysis (group 2). In patients with images, the last image was used for analysis only after dialysis.
The mean total kidney volume (TKV) (± SD) before hemodialysis initiation was 3132 ± 1413 mL and the mean TKV of the last image was 3047 ± 1323 mL in group 1. The mean TKV change rate (%) was - 5.2 ± 27.4% (P > 0.05) during follow-up of 3.9 ± 1.9 years in group 1. The mean TKV change rate was 2.8 ± 34.4% (P > 0.05) in group 2. The follow-up period after dialysis initiation ranged from 4.2 ± 4.7 to 8.0 ± 5.2 years.
The results suggest that the TKV of native polycystic kidneys decreases substantially after hemodialysis initiation. This reduction occurs mainly during the early post-hemodialysis period and followed by a slow enlargement of TKV.


Autosomal Dominant Polycystic Kidney Disease; Hemodialysis; Total Kidney Volume


  • Fig. 1 Change of native TKV in relation to years from dialysis. (A) Patients who had pre-and at least one post-dialysis image. (B) Patients who had only two or more post-dialysis images.


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