J Korean Med Sci.  2021 Nov;36(43):e294. 10.3346/jkms.2021.36.e294.

Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea

Affiliations
  • 1Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea
  • 2Department of Diagnostic Immunology, Seegene Medical Foundation, Seoul, Korea
  • 3Department of Laboratory Medicine, Daegu Fatima Hospital, Daegu, Korea
  • 4Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea
  • 5Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu, Korea
  • 6Department of Laboratory Medicine, Daegu Catholic University Hospital, Daegu, Korea
  • 7Department of Laboratory Medicine, Kyungpook National University Chilgok Hospital, Daegu, Korea

Abstract

Background
In Korea, the first community outbreak of coronavirus disease 2019 (COVID-19) occurred in Daegu on February 18, 2020. This study was performed to investigate the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies in healthcare workers (HCWs) at 6 major hospitals in Daegu.
Methods
Blood specimens of 2,935 HCWs at 6 major hospitals in Daegu from January 2021 to February 2021 were collected. Every specimen was tested for antibody against SARS-CoV-2 using both Elecsys Anti-SARS-CoV-2 electrochemiluminescence immunoassay (Roche Diagnostics, Rotkreuz, Switzerland) and R-FIND COVID-19 IgG/M/A enzyme-linked immunosorbent assay kit (SG medical Inc., Seoul, Korea) as screening tests. If 1 or more of these screening test results was positive, 2 additional antibody tests were performed using Abbott Anti-SARS-CoV-2 IgG assay (Abbott, Abbott Park, IL, USA) and cPass SARS-CoV-2 Neutralization Antibody Detection Kit (GenScript USA Inc., Piscataway, NJ, USA). If 2 or more of the total 4 test results were positive, it was determined as positive for the antibody against SARS-CoV-2.
Results
According to the criteria of SARS-CoV-2 antibody positivity determination, 12 subjects were determined as positive. The overall positive rate of the SARS-CoV-2 antibody was 0.41% (12/2,935). Of the 12 subjects determined as positive, 7 were diagnosed with COVID-19, and the remaining 5 were nondiagnosed cases of COVID-19.
Conclusion
In early 2021, the overall seroprevalence of SARS-CoV-2 antibody among HCW located in Daegu was 0.41%, and 0.17% excluding COVID-19 confirmed subjects. These results were not particularly high compared with the general public and were much lower than HCWs in other countries.

Keyword

COVID-19; SARS-CoV-2 Antibody; Healthcare Worker; Neutralizing Antibody
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