Korean J Transplant.  2021 Oct;35(Supple 1):S160. 10.4285/ATW2021.OP-1252.

Twenty-year longitudinal follow-up after liver transplantation: a single-center experience of 251 consecutive cases

• Hwang S
• Ahn CS
• Moon DB
• Ha TY
• Song GW
• Jung DH
• Park GC
• Namgoong JM
• Kim KM
• Lee SG

• KMID: 2521315
• DOI: http://doi.org/10.4285/ATW2021.OP-1252

Abstract

Background
The outcomes of liver transplantation (LT) has been improved, but the actual 20-year survival data are rarely presented.
Methods
A retrospective analysis of longitudinal follow-up data was performed to evaluate 20-year LT survivors. The institutional LT database was searched to identify patients who underwent primary LT during a 2-year period from January 2000 to December 2001. A study cohort of 251 patients was divided into three groups as adult living donor LT (LDLT; n=207), adult deceased donor LT (DDLT; n=22), and pediatric LT (n=22) groups.
Results
Common primary diseases were hepatitis B virus (HBV)-associated liver cirrhosis (n=177, 85.5%) and fulminant hepatic failure (n=14, 6.8%) in adult LDLT group; HBV-associated liver cirrhosis (n=19, 86.4%) in adult DDLT group; and biliary atresia (n=14, 63.6%) in pediatric LT group. The overall patient survival rates of adult LDLT cohort were 90.8% at 3 months, 86.0% at 1 year, 79.2% at 3 years, 77.3% at 5 years, 72.5% at 10 years, and 62.3% at 20 years, in which hepatocellular carcinoma recurrence, chronic rejection and de novo malignancy were the main cause of late patient death. The overall patient survival rates of adult DDLT cohort were 95.5% at 3 months, 86.4% at 1 year, 72.7% at 3 years, 72.7% at 5 years, 72.7% at 10 years, and 68.2% at 20 years. There was no statistical difference in overall patient survival rates between adult LDLT and DDLT groups (P=0.54). The overall patient survival rates of pediatric LT cohort were 95.5% at 3 months, 86.4% at 1 year, 86.4% at 3 years, 81.8% at 5 years, 81.8% at 10 years, and 77.3% at 20 years.
Conclusions
This is the first actual outcome of Korean single-center 20-year survival results of LT. It is necessary to analyze the causes of late graft failure in high-volume multicenter studies.