Korean J Orthod.  2021 Sep;51(5):304-312. 10.4041/kjod.2021.51.5.304.

Comparison of the effects of horizontal and vertical micro-osteoperforations on the biological response and tooth movement in rabbits

  • 1Department of Orthodontics, Graduate School of Clinical Dental Science, The Catholic University of Korea, Seoul, Korea.
  • 2Department of Orthodontics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 3SantaMonica College, Santa Monica, CA, USA.
  • 4Division of Oral and Maxillofacial Surgery, Department of Dentistry, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Uijeongbu, Korea.
  • 5Postgraduate Orthodontic Program, Arizona School of Dentistry & Oral Health, A.T. Still University, Mesa, AZ, USA.
  • 6International Scholar, Graduate School of Dentistry, Kyung Hee University, Seoul, Korea.
  • 7Department of Preventive Dental Sciences, College of Dentistry, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.
  • 8Department of Postgraduate Studies, Universidad Autonoma del Paraguay, Asuncion, Paraguay.


This study aimed to compare the amount of tooth movement after multiple horizontal (MH) and single vertical (SV) micro-osteoperforations (MOPs), and evaluate the histological changes after orthodontic force application in rabbits.
The mandibles of 24 white rabbits were subjected to two experimental interventions: MH and SV MOPs. Defect volume of the MOPs between the two groups was kept similar. A force of 100 cN was applied via a coil spring between the incisor teeth and the first premolars. The amount of tooth movement was measured. Differences in the amount of tooth movement and bone variables at three time points and between the two groups were evaluated using repeated-measures analysis of variance.
The first premolar showed a mesial movement of 1.47 mm in the MH group and 1.84 mm in the SV group, which was significantly different at Week 3 (p < 0.05). No significant difference was observed in bone volume and bone fraction between the groups. Tartrate-resistant acidic phosphatase-positive cell count was also significantly greater at Week 3 than at Week 1 in both the SV and MH groups.
The amount of tooth movement showed significant differences between Weeks 1 and 3 in the SV and MH MOP groups, but showed no differences between the two groups. Therefore, SV MOP could be considered an effective tool for enhancing tooth movement, especially for molar distalization, uprighting, and protraction to an edentulous area.


Corticotomy; Tooth movement; Bone biology; Micro-osteoperforation
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