Korean J Orthod.  2021 Sep;51(5):304-312. 10.4041/kjod.2021.51.5.304.

Comparison of the effects of horizontal and vertical micro-osteoperforations on the biological response and tooth movement in rabbits

• Kim Sg
• Kook YA
• Lim HJ
• Park P
• Lee W
• Park JH
• Bayome M
• Kim Y

• KMID: 2520370
• DOI: http://doi.org/10.4041/kjod.2021.51.5.304

Abstract

Objective
This study aimed to compare the amount of tooth movement after multiple horizontal (MH) and single vertical (SV) micro-osteoperforations (MOPs), and evaluate the histological changes after orthodontic force application in rabbits.
Methods
The mandibles of 24 white rabbits were subjected to two experimental interventions: MH and SV MOPs. Defect volume of the MOPs between the two groups was kept similar. A force of 100 cN was applied via a coil spring between the incisor teeth and the first premolars. The amount of tooth movement was measured. Differences in the amount of tooth movement and bone variables at three time points and between the two groups were evaluated using repeated-measures analysis of variance.
Results
The first premolar showed a mesial movement of 1.47 mm in the MH group and 1.84 mm in the SV group, which was significantly different at Week 3 (p < 0.05). No significant difference was observed in bone volume and bone fraction between the groups. Tartrate-resistant acidic phosphatase-positive cell count was also significantly greater at Week 3 than at Week 1 in both the SV and MH groups.
Conclusions
The amount of tooth movement showed significant differences between Weeks 1 and 3 in the SV and MH MOP groups, but showed no differences between the two groups. Therefore, SV MOP could be considered an effective tool for enhancing tooth movement, especially for molar distalization, uprighting, and protraction to an edentulous area.

Keyword

Corticotomy; Tooth movement; Bone biology; Micro-osteoperforation

Figure

• 

  Figure 1 A, Three-dimensional micro-computed tomography reconstructed scan of the left-sided multiple horizontal (MH) micro-osteoperforations (MOPs) and the right-sided single vertical (SV) MOP. B, A force of 100 cN is applied by connecting the anterior teeth to the first premolars by using nickel-titanium closed-coil springs. C, Design of the six MH MOPs and the SV MOP. P1, first premolar; P2, second premolar.

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  Figure 2 Tooth movement distance. A, Occlusal section. B, Sagittal section; white arrow, the amount of tooth movement. P1, first premolar; P2, second premolar; Rt, right.

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  Figure 3 Amount of tooth movement at 1, 2, and 3 weeks (mm). MH, multiple horizontal micro-osteoperforations; SV, single vertical micro-osteoperforation.

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  Figure 4 Micro-computed tomography evaluation. A, Bone volume. B, Bone fraction. MH, multiple horizontal micro-osteoperforations; SV, single vertical micro-osteoperforation.

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  Figure 5 Tartrate-resistant acidic phosphatase (TRAP)-positive cell count comparison between the groups and time points. MH, multiple horizontal micro-osteoperforations; SV, single vertical micro-osteoperforation.

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  Figure 6 Microphotograph of the periodontal tissues stained with tartrate-resistant acidic phosphatase (TRAP) at ×200 magnification. A–C, Multiple horizontal micro-osteoperforations at Weeks 1, 2, and 3, respectively. D–F, Single vertical micro-osteoperforation at Weeks 1, 2, and 3, respectively. TRAP-positive cells are detectable along the resorbed alveolar bone on the compression side.

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  Figure 7 Microphotograph of a buccolingual section at the mesial periodontium of the first premolar stained with hematoxylin and eosin at ×40 magnification. A–C, Multiple horizontal micro-osteoperforations at Weeks 1, 2, and 3, respectively. D–F, Single vertical micro-osteoperforation at Weeks 1, 2, and 3, respectively. Note the widened periodontal ligament (PDL) space in C and F. ALV, alveolar bone.

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