Ann Rehabil Med.  2021 Aug;45(4):304-313. 10.5535/arm.21087.

A Single Bout of Constant-Load Exercise Test for Estimating the Time Constant of Oxygen Uptake Kinetics in Individuals With Stroke

Affiliations
  • 1Department of Physical Therapy, School of Health Sciences, Shinshu University, Nagano, Japan
  • 2Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan
  • 3Department of Rehabilitation Medicine I, School of Medicine, Fujita Health University, Aichi, Japan

Abstract


Objective
To examine the relationship between the time constant of oxygen uptake kinetics during the onset of exercise (τVO2) estimated from a single exercise bout and that obtained from three averaged exercise bouts in individuals with stroke.
Methods
Twenty participants with stroke performed three bouts of a constant-load pedaling exercise at approximately 80% of the workload corresponding to the ventilatory threshold to estimate τVO2. The VO2 data from the first trial of three bouts were used to estimate τVO2 for a single bout. Additionally, data collected from three bouts were ensemble-averaged to obtain τVO2 for three averaged bouts as the criterion.
Results
There was a very high correlation between τVO2 for a single bout (34.8±14.0 seconds) and τVO2 for three averaged bouts (38.5±13.4 seconds) (r=0.926, p<0.001). However, τVO2 for a single bout was smaller than that for three averaged bouts (p=0.006).
Conclusion
τVO2 for a single bout could reflect the relative difference in τVO2 for three averaged bouts among individuals with stroke. However, it should be noted that τVO2 for a single bout may be underestimated compared to τVO2 for three averaged bouts.

Keyword

Cerebrovascular disorders, Exercise test, Oxygen consumption, Rehabilitation

Figure

  • Fig. 1. Flow chart of study participants.

  • Fig. 2. Typical oxygen uptake kinetics during exercise onset obtained from a single bout (A) and the average of three exercise bouts (B). Model fits on the data are displayed with a solid line. The vertical dashed line indicates the onset of exercise. CI, confidence interval; τVO2, time constant of oxygen uptake kinetics; VO2, oxygen uptake.

  • Fig. 3. Correlations between a single bout and three averaged exercise bouts for the baseline VO2 value (A), the amplitude of increase in VO2 (B), the time delay (C), and τVO2 (D). A high to very high correlation is shown between a single bout and three averaged exercise bouts for all VO2 kinetics parameters (p<0.001). A linear regression model (D) to convert τVO2 estimated from a single exercise bout to that obtained from the average of three exercise bouts is as follows: τVO2 for three averaged bouts = 0.887 × τVO2 for a single bout + 7.618 (R2=0.857, p<0.001). τVO2, time constant of oxygen uptake kinetics; VO2, oxygen uptake.

  • Fig. 4. Comparisons of the baseline VO2 value (A), the amplitude of increase in VO2 (B), the time delay (C), τVO2 (D), and 95% CI for τVO2 (E). τVO2 estimated from the first trial is significantly smaller than that obtained from the third trial (p=0.008). CI, confidence interval; τVO2, time constant of oxygen uptake kinetics; VO2, oxygen uptake.


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