Int J Thyroidol.  2021 May;14(1):42-45. 10.11106/ijt.2021.14.1.42.

A Case of Hyperparathyroidism Caused by Intrathyroidal Parathyroid Adenoma

Affiliations
  • 1Department of Otorhinolaryngology-Head & Neck Surgery, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea
  • 2Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea

Abstract

Hyperparathyroidism is a common endocrine disorder, but intrathyroidal parathyroid adenoma is extremely rare. We report a on a case of hyperparathyroidism caused by intrathyroidal parathyroid adenoma. This case is important in that it affects an effective test for the diagnosis of intrathyroidal parathyroid adenoma, and shows the decision of the treatment process and the results.

Keyword

Hyperparathyroidism; Ectopic parathyroid; Parathyroid adenoma; Intrathyroidal parathyroid adenoma

Figure

  • Fig. 1 Computed tomography of the neck. The scan with contrast enhancement shows a heterogeneous soft tissue mass, clearly defined, within the left thyroid lobe (white arrows). (A) Axial view. (B) Coronal view.

  • Fig. 2 Thyroid ultrasonography showed 1.77×1.13×3.32 cm hypoechoic nodule in left thyroid gland.

  • Fig. 3 Technesium (Tc)-99m sestamibi parathyroid scan. Early and delayed scintigrams reveal focal accumulation of increased radiotracer uptake in the left lobe of the thyroid.

  • Fig. 4 Gross photo of specimen. (A) Exposed left side of thyroid tissue (arrowheads). (B) The gross pathology specimen of left thyroid.

  • Fig. 5 Histopathologic findings of left thyroid gland. Microscopic findings show well-encapsulated parathyroid adenoma inside the normal thyroid tissue. (A) Hematoxylin and Eosin (H&E) stain, ×40, (B) H&E stain, ×100 (arrows). The tumor cells showed diffuse strong positivity for GATA3, but absence of staining for TTF1. (C) GATA3 immune stain, ×40. (D) TTF1 immune stain, ×40.


Reference

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