Cancer Res Treat.  2021 Apr;53(2):541-548. 10.4143/crt.2020.1001.

Second Primary Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers after Breast Cancer Diagnosis: Korea Central Cancer Registry

Affiliations
  • 1Center for Gynecologic Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
  • 2Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
  • 3Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, Korea
  • 4Cancer Healthcare Research Branch, Research Institute, National Cancer Center, Goyang, Korea
  • 5Division of Cancer Control and Policy, National Cancer Control Institute, National Cancer Center, Goyang, Korea
  • 6Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea
  • 7Division of Tumor Immunology, Research Institute, National Cancer Center, Goyang, Korea

Abstract

Purpose
A prior history of breast cancer is a risk factor for the subsequent development of primary peritoneal, epithelial ovarian, and fallopian tubal (POFT) cancers. This study aimed to estimate the incidence of secondary POFT malignancy in breast cancer patients and the clinical outcomes of primary and secondary POFT cancer.
Materials and Methods
We searched the Korea Central Cancer Registry to find patients with primary and secondary POFT cancer who had breast cancer in 1999-2017. The incidence rate and standardized incidence ratio were calculated. Additionally, we compared the overall survival of patients with primary and secondary POFT cancer.
Results
Based on the age-standardized rate, the incidence of second primary POFT cancer after breast cancer was 0.0763 per 100,000 women, which increased in Korea between 1999 and 2017. Among the 30,366 POFT cancer patients, 25,721 were primary POFT cancer only, and 493 had secondary POFT cancer after a breast cancer diagnosis. Second primary POFT cancer patients were older at the time of diagnosis (55 vs. 53, p < 0.001) and had a larger proportion of serous histology (68.4% vs. 51.2%, p < 0.001) than patients with primary POFT. There were no differences between the two groups in tumor stage at diagnosis. The 5-year overall survival rates were 60.2% and 56.3% for primary and secondary POFT cancer, respectively (p=0.216).
Conclusion
The incidence of second primary POFT cancer after breast cancer increased in Korea between 1999 and 2017. Besides, second primary POFT cancer patients were diagnosed at older ages and had more serous histology.

Keyword

Primary peritoneal; Epithelial ovarian cancer; Fallopian tube neoplasms; Ovarian neoplasms; Breast neoplasms; Second primary neoplasms
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