Ann Lab Med.  2021 Jul;41(4):409-413. 10.3343/alm.2021.41.4.409.

Phospholipase C Beta 2 Protein Overexpression Is a Favorable Prognostic Indicator in Newly Diagnosed Normal Karyotype Acute Myeloid Leukemia

Affiliations
  • 1Department of Medical Laboratory Science, Gimhae College, Gimhae, Korea
  • 2Brain Korea 21 Plus Program, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea
  • 3College of Korean Medicine, Dongshin University, Naju, Korea
  • 4Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea
  • 5Department of Biology, Sunchon National University, Sunchon, Korea

Abstract

Phospholipase C beta 2 (PLC-β2) regulates various essential functions in cell signaling, differentiation, growth, and mobility. We investigated the clinical implications of PLC-β2 protein expression in newly diagnosed normal karyotype acute myeloid leukemia (NKAML). The PLC-β2 expression status in bone marrow tissues obtained from 101 patients with NK-AML was determined using semiquantitative immunohistochemistry (IHC). IHC results were compared with those for known prognostic markers. Using a cutoff score for positivity of 7.0, the PLC-β2 overexpression group showed superior overall survival (OS) (72.6% vs. 26.5%; P = 0.016) and low hazard ratio (HR) (0.453; P = 0.019) compared with the PLC-β2 low-expression group. The PLC-β2 overexpression group showed no significant gain in event-free survival (50.6% vs. 43.0%, P =0.465) and HR (0.735; P =0.464). Among the known prognostic markers, only FLT3-ITD positivity was associated with a significantly low OS and high HR. In conclusion, PLC-β2 overexpression was associated with favorable OS in NK-AML patients. Our results suggest that PLC-β2 expression assessment using IHC allows prognosis prediction in NK-AML.

Keyword

Phospholipase C beta 2 protein; normal karyotype acute myeloid leukemia; prognosis
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