Ann Lab Med.  2021 Mar;41(2):243-246. 10.3343/alm.2021.41.2.243.

A Case of IgG4-related Disease With Bone Marrow Involvement: Bone Marrow Findings and Flow Cytometric Immunophenotyping of Plasma Cells

Affiliations
  • 1Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 2Department of Laboratory Medicine, Inje University College of Medicine, Busan Baik Hospital, Busan, Korea
  • 3Department of Laboratory Medicine, Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea


Figure

  • Fig. 1 Morphologic and IHC findings of PB and BM samples, and flow cytometric immunophenotyping of PC. (A) Eosinophilia, poikilocytosis (schistocytes and spherocytes), and rouleaux formation (PB, Wright stain, × 400). (B) Increased numbers of PC including immature forms with slightly high NC ratio, nucleolus, and perinuclear halo (BM aspirate, Wright stain, × 1,000). (C) Increased number of eosinophils (BM aspirate, Wright stain, × 1,000). (D) Increased number of eosinophils and PC (BM biopsy, H & E stain, × 400). (E) Increased number of PC (BM clot section, IHC stain for CD138, × 1,000). (F) Increased numbers of IgG4+ PC (BM biopsy, IHC stain for IgG4, × 1,000). (G, H) Presence of atypical PC with the immunophenotypes CD38+/CD138dim/CD56−/CD19low/CD45+ in PB and CD38+/CD138+/CD56+/CD19low/CD45low in BM aspirates. Abbreviations: IHC, immunohistochemistry; PB, peripheral blood; BM, bone marrow; PC, plasma cells.


Cited by  1 articles

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Seungwan Chae, JeongJoong Lee, Hanwool Cho, Hyojin Chae, Eun-Jee Oh
Ann Lab Med. 2023;43(1):108-110.    doi: 10.3343/alm.2023.43.1.108.


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