J Bacteriol Virol.  2020 Sep;50(3):175-180. 10.4167/jbv.2020.50.3.175.

Recent Research and Knowledge on Treatment for Hepatitis B

Affiliations
  • 1Division of Viral Disease Research, Center for Infectious Disease Research, Korea National Institute of Health, Chungbuk 28159, Republic of Korea

Abstract

Hepatitis B virus (HBV) infection is a major public health problem, with some 250 million people currently at high risk of developing chronic liver diseases. The current antiviral treatment for chronic hepatitis B (CHB) is effective in controlling viral replication but fails to achieve a complete cure. Since the identification of sodium taurocholate cotransport polypeptide (NTCP) as an HBV receptor, anti-HBV drugs targeting viral entry, capsid assembly, cccDNA, transcription, and secretion have been developed. In this paper, the potential inhibitors in various steps of the HBV life cycle are summarized.

Keyword

Hepatitis B virus; Drugs; cccDNA; ISG20
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