Yeungnam Univ J Med.  2021 Jan;38(1):34-38. 10.12701/yujm.2020.00234.

Association between gestational age at delivery and lymphocyte-monocyte ratio in the routine second trimester complete blood cell count

• Cha HH
• Kim JM
• Kim HM
• Kim MJ
• Chong GO
• Seong WJ

• KMID: 2512064
• DOI: http://doi.org/10.12701/yujm.2020.00234

Abstract

Background
We aimed to determine whether routine second trimester complete blood cell (CBC) count parameters, including neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR), could predict obstetric outcomes.
Methods
We included singleton pregnancies for which the 50-g oral glucose tolerance test and CBC were routinely performed between 24 and 28 weeks of gestation in our outpatient clinic from January 2015 to December 2017. The subjects were divided into three groups according to their pregnancy outcomes as follows: group 1, spontaneous preterm births, including preterm labor and preterm premature rupture of membranes; group 2, indicated preterm birth due to maternal, fetal, or placental causes (hypertensive disorder, fetal growth restriction, or placental abruption); and group 3, term deliveries, regardless of the indication of delivery. We compared the CBC parameters using a bivariate correlation test.
Results
The study included 356 pregnancies. Twenty-eight subjects were in group 1, 20 in group 2, and 308 in group 3. There were no significant differences between the three groups in neutrophil, monocyte, lymphocyte, and platelet counts. Although there was no significant difference in NLR, LMR, and PLR between the three groups, LMR showed a negative correlation with gestational age at delivery (r=−0.126, p=0.016).
Conclusion
We found that a higher LMR in the second trimester was associated with decreased gestational age at delivery. CBC parameters in the second trimester of pregnancy could be used to predict adverse obstetric outcomes.

Keyword

Lymphocyte-monocyte ratio; Neutrophil-lymphocyte ratio; Preterm

Figure

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  Fig. 1. Correlations of gestational age at delivery with complete blood cell count parameters. (A) Neutrophil-to-lymphocyte ratio (NLR) does not show a statistically significant correlation with GAD (r=0.095, p=0.074). (B) Lymphocyte-to-monocyte ratio (LMR) shows a negative correlation with GAD (r=−0.126, p=0.016). (C) Platelet-to-lymphocyte ratio (PLR) does not show a statistically significant correlation with GAD (r=0.063, p=0.216). GAD, gestational age at delivery.

Reference

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