Nat Prod Sci.
2020 Dec;26(4):279-282. 10.20307/nps.2020.26.4.279.
A New Cytotoxic Compound from Methanol Extract of Koordersiodendron pinnatum Merr. Leaves
- Affiliations
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- 1Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, 15314 Banten, Indonesia
- KMID: 2511945
- DOI: http://doi.org/10.20307/nps.2020.26.4.279
Abstract
- Chemical investigation of the methanol extract of Koordersiodendron pinnatum Merr. leaves resulted a new naphthalene derivative, (Z)-4-(tetradec-3-enyl)naphthalene-1,2,7-triol (1), together with three known compounds, β-sitosterol (2), 20-epibryonolic acid (3), and scopoletin (4). The structure of the new compound was elucidated based on spectroscopic evidence. The isolated compounds (1-4) were tested their cytotoxic activities against the P-388 murine leukemia cell line and compound 1 has highest activity with IC50 1.94 ㎛
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