Clin Mol Hepatol.  2020 Oct;26(4):411-429. 10.3350/cmh.2020.0049.

Comparison of clinical practice guidelines for the management of chronic hepatitis B: When to start, when to change, and when to stop

Affiliations
  • 1Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
  • 2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
  • 3Department of Internal Medicine, Inje University College of Medicine, Seoul, Korea
  • 4Department of Health Medicine, Asan Medical Center, Seoul, Korea
  • 5Department of Internal Medicine, College of Medicine, the Catholic University of Korea, Seoul, Korea
  • 6Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 7Department of Internal Medicine, Soonchunhyang University College of Medicine, Chonan, Korea
  • 8Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Abstract

Clinical practice guidelines are important for guiding the management of specific diseases by medical practitioners, trainees, and nurses. In some cases, the guidelines are utilized as a reference for health policymakers in controlling diseases with a large public impact. With this in mind, practice guidelines for the management of chronic hepatitis B (CHB) have been developed in the United States, Europe, and Asian-Pacific regions to suggest the best-fit recommendations for each social and medical circumstance. Recently, the Korean Association for the Study of the Liver published a revised version of its clinical practice guidelines for the management of CHB. The guidelines included updated information based on newly available antiviral agents, the most recent opinion on the initiation and cessation of treatment, and updates for the management of drug resistance, partial virological response, and side effects. Additionally, CHB management in specific situations was comprehensively revised. This review compares the similarities and differences among the various practice guidelines to identify unmet needs and improve future recommendations.

Keyword

Hepatitis B, Chronic; Hepatitis B virus; Clinical practice guidelines
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