J Lipid Atheroscler.  2020 Sep;9(3):419-434. 10.12997/jla.2020.9.3.419.

The Key Role of DNA Methylation and Histone Acetylation in Epigenetics of Atherosclerosis

Affiliations
  • 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science, Seoul National University, Seoul, Korea
  • 2Interdisciplinary Program in Stem Cell Biology, Graduate School of Medicine, Seoul National University, Seoul, Korea
  • 3Department of Orthopedic Surgery, Seoul National University Hospital, Seoul, Korea
  • 4Strategic Center of Cell and Bio Therapy for Heart, Diabetes & Cancer, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea
  • 5Department of Medicine, College of Medicine, Seoul National University, Seoul, Korea

Abstract

Atherosclerosis, which is the most common chronic disease of the coronary artery, constitutes a vascular pathology induced by inflammation and plaque accumulation within arterial vessel walls. Both DNA methylation and histone modifications are epigenetic changes relevant for atherosclerosis. Recent studies have shown that the DNA methylation and histone modification systems are closely interrelated and mechanically dependent on each other. Herein, we explore the functional linkage between these systems, with a particular emphasis on several recent findings suggesting that histone acetylation can help in targeting DNA methylation and that DNA methylation may control gene expression during atherosclerosis.

Keyword

DNA methylation; Histones; Acetylation; Atherosclerosis
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