Lab Anim Res.  2020 Jun;36(2):108-118. 10.1186/s42826-020-00045-1.

Patient-derived xenografts as compatible models for precision oncology

Affiliations
  • 1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
  • 2Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
  • 3Medical Research Center, Genomic Medicine Institute (GMI), Seoul National University, Seoul, Korea

Abstract

Cancer is a very heterogeneous disease, displaying heterogeneity between patients (inter-tumoral heterogeneity) and heterogeneity within a patient (intra-tumoral heterogeneity). Precision oncology is a diagnostic and therapeutic approach for cancers based on the stratification of patients using genomic and molecular profiling of tumors. To develop diagnostic and therapeutic tools for the application of precision oncology, appropriate preclinical mouse models that reflect tumor heterogeneity are required. Patient-derived xenograft (PDX) models are generated by the engraftment of patient tumors into immunodeficient mice that retain several aspects of the patient’s tumor characteristics, including inter-tumoral heterogeneity and intra-tumoral heterogeneity. Therefore, PDX models can be applied in various developmental steps of cancer diagnostics and therapeutics, such as biomarker development, companion diagnostics, drug efficacy testing, overcoming drug resistance, and co-clinical trials. This review summarizes the diverse aspects of PDX models, addressing the factors considered for PDX generation, application of PDX models for cancer research, and future directions of PDX models.

Keyword

Patient-derived xenograft; Precision oncology; Cancer preclinical model; Tumor heterogeneity; Targeted therapeutics; Drug efficacy test
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