Korean J Psychosom Med.  2020 Jun;28(1):36-41. 10.22722/KJPM.2020.28.1.36.

A Retrospective Study on the Effect of 1-Year Clozapine Administration on Platelet Activity in Patients with Schizophrenia or Schizoaffective Disorder

Affiliations
  • 1Department of Psychiatry, College of Medicine, Konyang University, Daejeon, Korea
  • 2Konyang University Myunggok Medical Research Institute, Daejeon, Korea
  • 3Department of Laboratory Medicine, Konyang University Hospital, Daejeon, Korea

Abstract


Objectives
:Clozapine has been known to increase the possibility of developing cardio/cerebrovascular diseases, and the platelet activation has been deemed to be related to the occurrence of them. In author’s previous study, we observed the increase of platelet activity with short-term clozapine administration. This study was conducted, as a follow-up study, to investigate the effect of clozapine on the platelet activity when administered continuously for long-term period of time of 1 year.
Methods
:The medical records of the patients with schizophrenia or schizoaffective disorder who were treated with clozapine for 1 year were retrospectively reviewed. The degree of platelet activation was assessed by measuring the mean platelet component.
Results
:Total of 24 patients were enrolled. 9 of them (37.5%) were male and 15 of them (62.5%) were female. In the Wilcoxon sign-ranks test, no significant change was observed between the mean platelet factor values at the beginning and at the end of one year.
Conclusions
:No significant changes of mean platelet activity were observed after continued administration of clozapine for 1 year. Considering the author’s previous findings that observed a prominent decrease of mean platelet component after short-term clozapine administration, the result of this study suggests the possibility that the activity of the platelet may change depending on the duration of the clozapine administration.

Keyword

Clozapine; Mean platelet component; Platelet activation; Metabolic side effects; Thromboembolic disease
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