Clin Endosc.  2020 May;53(3):374-376. 10.5946/ce.2019.192.

Hepatosplenic T-Cell Lymphoma Diagnosed by Endoscopic Ultrasound-Guided Fine-Needle Biopsy

• Shibata Y
• Miyamoto M
• Shinomiya W
• Kirita K
• Motomura S
• Hidai H
• Hagino T
• Ito Y

• KMID: 2502775
• DOI: http://doi.org/10.5946/ce.2019.192

Figure

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  Fig. 1. Abdominal computed tomography (CT), 18F-Fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/CT, and endoscopic ultrasound images for a patient with hepatosplenic T-cell lymphoma. (A) Abdominal CT scan showing marked splenomegaly. (B) 18F-FDG PET/CT scan showing abnormal accumulation of FDG in the spleen. (C) Endoscopic ultrasound images showing marked splenomegaly but no noticeable mass formation. The spleen was punctured by a 22-gauge biopsy needle.

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  Fig. 2. Histologic features in a patient with hepatosplenic T-cell lymphoma. (A) High power view (×400) with hematoxylin and eosin staining shows diffuse infiltration of atypical lymphocytes into the sinusoids of the spleen. Immunohistochemical analysis at ×400 showing atypical lymphocytes that are CD3-positive (B) but CD4-negative (C), CD8-negative (D), and CD20-negative (E).

Reference

1. Eloubeidi MA, Varadarajulu S, Eltoum I, Jhala D, Chhieng DC, Jhala NC. Transgastric endoscopic ultrasound-guided fine-needle aspiration biopsy and flow cytometry of suspected lymphoma of the spleen. Endoscopy. 2006; 38:617–620.

2. Iwashita T, Yasuda I, Tsurumi H, et al. Endoscopic ultrasound-guided fine needle aspiration biopsy for splenic tumor: a case series. Endoscopy. 2009; 41:179–182.

3. Saab S, Challita Y, Holloman D, Hathaway K, Kahaleh M, Nieto J. Case series review of the safety and efficacy of endoscopic ultrasound-guided splenic mass core biopsy. Clin Endosc. 2018; 51:600–601.

4. Thai A, Prindiville T. Hepatosplenic T-cell lymphoma and inflammatory bowel disease. J Crohns Colitis. 2010; 4:511–522.

5. Deepak P, Sifuentes H, Sherid M, Stobaugh D, Sadozai Y, Ehrenpreis ED. T-cell non-Hodgkin’s lymphomas reported to the FDA AERS with tumor necrosis factor-alpha (TNF-alpha) inhibitors: results of the REFURBISH study. Am J Gastroenterol. 2013; 108:99–105.

6. Macon WR, Levy NB, Kurtin PJ, et al. Hepatosplenic alphabeta T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic gammadelta T-cell lymphomas. Am J Surg Pathol. 2001; 25:285–296.

7. Yabe M, Miranda RN, Medeiros LJ. Hepatosplenic T-cell lymphoma: a review of clinicopathologic features, pathogenesis, and prognostic factors. Hum Pathol. 2018; 74:5–16.

8. Kudo T, Kawakami H, Hayashi T, et al. High and low negative pressure suction techniques in EUS-guided fine-needle tissue acquisition by using 25-gauge needles: a multicenter, prospective, randomized, controlled trial. Gastrointest Endosc. 2014; 80:1030–1037. e1.

9. Nakai Y, Isayama H, Chang KJ, et al. Slow pull versus suction in endoscopic ultrasound-guided fine-needle aspiration of pancreatic solid masses. Dig Dis Sci. 2014; 59:1578–1585.

10. Gerke H, Rizk MK, Vanderheyden AD, Jensen CS. Randomized study comparing endoscopic ultrasound-guided Trucut biopsy and fine needle aspiration with high suction. Cytopathology. 2010; 21:44–51.