Clin Exp Reprod Med.  2020 Jun;47(2):135-139. 10.5653/cerm.2019.03349.

Cumulative live birth rate after up to three consecutive embryo transfer cycles in women with poor ovarian response

• Kim SJ
• Lee D
• Kim SK
• Jee BC
• Kim SH

• KMID: 2502748
• DOI: http://doi.org/10.5653/cerm.2019.03349

Abstract

Objective
In the present study, we aimed to retrospectively evaluate the cumulative live birth rate (LBR) after up to three consecutive embryo transfer (ET) cycles, either fresh or frozen, in women with expected poor ovarian response (ePOR).
Methods
We selected 115 women who entered the first in vitro fertilization (IVF) cycle between August 2013 and July 2016. The women were divided into an ePOR group (37 women) and a non-ePOR group (78 women). All women in the ePOR group were ≥40 years old or had serum anti-Müllerian hormone levels of less than 1.1 ng/mL at the time of the first IVF cycle. Live birth outcomes were monitored until December 2017. The cumulative LBR (with both conservative and optimistic estimates) was calculated according to the serial number of ET cycles.
Results
After up to three ET cycles, the overall cumulative LBR was significantly lower in the ePOR group than in the non-ePOR group (conservative estimate, 10.8% vs. 44.9%, respectively; optimistic estimate, 14.7% vs. 56.1%, respectively; log-rank test, p=0.003).
Conclusion
Women with ePOR exhibited a lower cumulative LBR than women in the non-ePOR group, and this information should be provided to ePOR women during counseling before starting IVF.

Keyword

Embryo transfer; Fertilization; Live birth; Pregnancy rate